Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung Hideki Yamashita, MD, Shinji Akamine, MD, Yorihisa Sumida,

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Presentation transcript:

Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung Hideki Yamashita, MD, Shinji Akamine, MD, Yorihisa Sumida, MD, Masao Inoue, MD, Takahiro Sawada, MD, Takeshi Nagayasu, MD, Tadayuki Oka, MD The Annals of Thoracic Surgery Volume 78, Issue 1, Pages 292-297 (July 2004) DOI: 10.1016/j.athoracsur.2003.12.025

Fig 1 Mean pulmonary arterial pressure. Data are shown as mean ± SD (*p < 0.05 versus control group). Circles = sham; squares = controls; diamonds = nitric oxide inhalation. (min. = minutes; pre = prereperfusion.) The Annals of Thoracic Surgery 2004 78, 292-297DOI: (10.1016/j.athoracsur.2003.12.025)

Fig 2 Arterial oxygen tension (Pao2). Data are shown as mean ± SD (*p < 0.05 versus control group). Circles = sham; squares = controls; diamonds = nitric oxide inhalation. (min. = minutes; pre = prereperfusion.) The Annals of Thoracic Surgery 2004 78, 292-297DOI: (10.1016/j.athoracsur.2003.12.025)

Fig 3 Lung wet-to-dry weight ratio after 120 minutes of reperfusion. Data are shown as mean ± SD. (NO = nitric oxide.) The Annals of Thoracic Surgery 2004 78, 292-297DOI: (10.1016/j.athoracsur.2003.12.025)

Fig 4 Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) staining after ischemia-reperfusion: (a) prereperfusion; (b) 15 minutes after reperfusion; (c) 30 minutes after reperfusion; (d) 60 minutes after reperfusion; (e) 120 minutes after reperfusion; (f) quantification of TUNEL-positive cells at prereperfusion (pre) or after 15, 30, 60, and 120 minutes of reperfusion. Date are shown as mean ± SD (*p < 0.05 versus prereperfusion). The Annals of Thoracic Surgery 2004 78, 292-297DOI: (10.1016/j.athoracsur.2003.12.025)

Fig 5 Hematoxylin & eosin (HE) staining and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) staining after 120 minutes of reperfusion. (a–c) HE staining; (d–f) TUNEL staining. (a) and (d) are the sham group; (b) and (e) are the control group; (c) and (f) are the inhaled nitric oxide group. The Annals of Thoracic Surgery 2004 78, 292-297DOI: (10.1016/j.athoracsur.2003.12.025)

Fig 6 Quantification of terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL)-positive cells after 120 minutes of reperfusion. Data are shown as mean ± SD. Inhaled nitric oxide (NO) reduced the increase in TUNEL-positive cells compared with controls. The Annals of Thoracic Surgery 2004 78, 292-297DOI: (10.1016/j.athoracsur.2003.12.025)