Effect of perfusion flow rate on tissue oxygenation in newborn piglets during cardiopulmonary bypass Gregory Schears, MD, Steven E Schultz, MD, Jennifer.

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Presentation transcript:

Effect of perfusion flow rate on tissue oxygenation in newborn piglets during cardiopulmonary bypass Gregory Schears, MD, Steven E Schultz, MD, Jennifer Creed, BA, William J Greeley, MD, David F Wilson, PhD, Anna Pastuszko, PhD The Annals of Thoracic Surgery Volume 75, Issue 2, Pages 560-565 (February 2003) DOI: 10.1016/S0003-4975(02)04342-4

Fig 1 Relationship between brain oxygenation and perfusion flow rate during cardiopulmonary bypass (CPB) in patent ductus arteriosus ligated (PDA-L) and nonligated (PDA-NL) newborn piglets. The results are expressed as the means ± SEM for six experiments. a* = p < 0.05; a** = p < 0.01 for significant difference from pre-CPB values in PDA-NL group of animals. b* = p < 0.05; b** = p < 0.01 for significant difference between PDA-L and PDA-NL groups of animals, as determined by one-way analysis of variance, followed by the Wilcoxon signed-rank test. The Annals of Thoracic Surgery 2003 75, 560-565DOI: (10.1016/S0003-4975(02)04342-4)

Fig 2 Oxygenation of the heart at different perfusion flow rates in patent ductus arteriosus ligated (PDA-L) and nonligated (PDA-NL) newborn piglets during cardiopulmonary bypass (CPB). The results are expressed as the means ± SEM for six experiments. a* = p < 0.05; a** = p < 0.005; a*** = p < 0.001 for significant difference from pre-CPB values in PDA-L group of animals. c** = p < 0.005; c*** = p < 0.001 for significant difference from pre-bypass values in PDA-NL group of animals as determined by one-way analysis of variance, followed by the Wilcoxon signed-rank test. The Annals of Thoracic Surgery 2003 75, 560-565DOI: (10.1016/S0003-4975(02)04342-4)

Fig 3 Oxygenation of the liver at different perfusion flow rates in patent ductus arteriosus ligated (PDA-L) and nonligated (PDA-NL) newborn piglets during cardiopulmonary bypass (CPB). The results are expressed as the means ± SEM for six experiments. a* = p < 0.05; a** = p < 0.01 for significant difference from pre-CPB values in PDA-L group of animals. c* = p < 0.05 for significant difference from pre-bypass values in PDA-NL group of animals as determined by one-way analysis of variance, followed by the Wilcoxon signed-rank test. The Annals of Thoracic Surgery 2003 75, 560-565DOI: (10.1016/S0003-4975(02)04342-4)

Fig 4 Dependence of intestine oxygenation on perfusion flow rates in the patent ductus arteriosus ligated (PDA-L) and nonligated (PDA-NL) newborn piglets during cardiopulmonary bypass (CPB). The results are expressed as the means ± SEM for six experiments. a* = p < 0.05; a** = p < 0.01 for significant difference from pre-CPB values in PDA-L group of animals. c* = p < 0.05; c** = p < 0.01 for significant difference from pre-CPB values in PDA-NL group of animals as determined by one-way analysis of variance, followed by the Wilcoxon signed-rank test. The Annals of Thoracic Surgery 2003 75, 560-565DOI: (10.1016/S0003-4975(02)04342-4)

Fig 5 Effect of varying perfusion flow on oxygen pressure in the skeletal muscle of patent ductus arteriosus ligated (PDA-L) and nonligated (PDA-NL) newborn piglets during cardiopulmonary bypass. The results are expressed as the means ± SEM for six experiments. The Annals of Thoracic Surgery 2003 75, 560-565DOI: (10.1016/S0003-4975(02)04342-4)