Pre-operative pressure pain thresholds do not meaningfully explain satisfaction or improvement in pain after knee replacement: a cohort study  Y.Y. Leung,

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Pre-operative pressure pain thresholds do not meaningfully explain satisfaction or improvement in pain after knee replacement: a cohort study  Y.Y. Leung, Z. Lim, Q. Fan, V. Wylde, S. Xiong, S.J. Yeo, N.N. Lo, H.C. Chong, W. Yeo, M.H. Tan, B. Chakraborty, S. Bak-Siew Wong, J. Thumboo  Osteoarthritis and Cartilage  Volume 27, Issue 1, Pages 49-58 (January 2019) DOI: 10.1016/j.joca.2018.09.003 Copyright © 2018 The Author(s) Terms and Conditions

Fig. 1 Flow diagram of the study. Osteoarthritis and Cartilage 2019 27, 49-58DOI: (10.1016/j.joca.2018.09.003) Copyright © 2018 The Author(s) Terms and Conditions

Fig. 2 Box plot of baseline PPT forearm and knee. A. Baseline PPT forearm as stratified by satisfaction at 6 months. B. Baseline PPT knee as stratified by satisfaction at 6 months. C. Baseline PPT forearm as stratified by pain improvement at 6 months. D. Baseline PPT knee as stratified by pain improvement at 6 months. Osteoarthritis and Cartilage 2019 27, 49-58DOI: (10.1016/j.joca.2018.09.003) Copyright © 2018 The Author(s) Terms and Conditions

Supplementary Figure 1 Directed acyclic graphs (DAG) visual representations of causal assumptions for defining confounding variables (red circles or light grey circles for latent variables) for estimating total effect of PPT on change of WOMAC pain. Exposure was PPT (green circle), the outcome was change of WOMAC pain (blue circle), and all possible interaction between variables were presented. Green line indicates possible causal path, red lines indicates confounding paths. A minimally sufficient set of variables that minimize bias for estimating the total effect on change in pain was: KL grading, anxiety, depression, expectations, number of painful sites and pain. Osteoarthritis and Cartilage 2019 27, 49-58DOI: (10.1016/j.joca.2018.09.003) Copyright © 2018 The Author(s) Terms and Conditions