A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response  Pooja Varshney, MD, Stacie.

Slides:



Advertisements
Similar presentations
Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy  Ravi S. Swamy, MD, Neha Reshamwala,
Advertisements

Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy  Scott.
Immunotherapy for Food Allergy: Are We There Yet?
Corinne A. Keet, MD, MS, Pamela A
A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,
Sublingual immunotherapy for peanut allergy: A randomized, double-blind, placebo- controlled multicenter trial  David M. Fleischer, MD, A. Wesley Burks,
Omalizumab facilitates rapid oral desensitization for peanut allergy
Fatty acids, inflammation, and asthma
Alison M. Hofmann, MD, Amy M. Scurlock, MD, Stacie M
Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy  Michael Kulis, PhD, Katie.
Advances in food allergy in 2015
Cow's milk epicutaneous immunotherapy in children: A pilot trial of safety, acceptability, and impact on allergic reactivity  Christophe Dupont, MD, PhD,
Stacie M. Jones, MD, Scott H. Sicherer, MD, A
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Ann-Marie M. Schoos, MD, PhD, Jacob D
Evaluation of BCG administration as an adjuvant to specific immunotherapy in asthmatic children with mite allergy  Andrea Cohon, MD, L. Karla Arruda,
Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy  Julie Wang, MD, Stacie M. Jones,
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study  John M. Brehm, MD, MPH, Brooke Schuemann, BS,
Is 9 more than 2 also in allergic airway inflammation?
A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy  Robert A.
Fatty acids, inflammation, and asthma
Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy  Kamal D. Srivastava, PhD, Alyssa Siefert,
Omalizumab facilitates rapid oral desensitization for peanut allergy
Clara cell 16-kd protein downregulates TH2 differentiation of human naive neonatal T cells  Sofi Johansson, MSc, Göran Wennergren, MD, PhD, Nils Åberg,
Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model  Lucie Mondoulet, PhD, Vincent Dioszeghy, PhD, Emilie Puteaux,
A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy  Justin M. Skripak, MD, Scott D. Nash, MD, Hannah.
Single–tree nut immunotherapy attenuates allergic reactions in mice with hypersensitivity to multiple tree nuts  Mike Kulis, PhD, Yifan Li, BS, Hannah.
Administration of a probiotic with peanut oral immunotherapy: A randomized trial  Mimi L.K. Tang, PhD, Anne-Louise Ponsonby, PhD, Francesca Orsini, MSc,
A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,
Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA 
IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life 
A. Wesley Burks, MD, Robert A. Wood, MD, Stacie M. Jones, MD, Scott H
Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti–IL-4: A randomized controlled trial  Adam M. Chaker, MD, Mohamed H. Shamji,
Laurent Pons, PhD, Usha Ponnappan, PhD, Renée A
Phillip Lieberman, MD, Michael Tankersley, MD 
Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens  Brian P. Vickery, MD, Jing Lin, PhD, Michael Kulis, PhD, Zhiyan Fu,
Novel baseline predictors of adverse events during oral immunotherapy in children with peanut allergy  Yamini V. Virkud, MD, MA, MPH, A. Wesley Burks,
Allergen-specific immunotherapy with recombinant grass pollen allergens  Marek Jutel, MD, Lothar Jaeger, MD, Roland Suck, PhD, Hanns Meyer, Dipl Math,
Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation  Abel Suárez-Fueyo, PhD, Tania.
Skin prick test to egg white provides additional diagnostic utility to serum egg white– specific IgE antibody concentration in children  Adina Kay Knight,
Corinne A. Keet, MD, MS, Pamela A
Autophagy: Nobel Prize 2016 and allergy and asthma research
Advances in the approach to the patient with food allergy
House dust mite sublingual immunotherapy: Results of a US trial
Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy  Véronique Schulten, PhD,
Is intralymphatic immunotherapy ready for clinical use in patients with grass pollen allergy?  Marianne Witten, MD, PhD, Hans-Jørgen Malling, MD, Lars.
Effect of aging on sputum inflammation and asthma control
Brian P. Vickery, MD, Jelena P. Berglund, PhD, Caitlin M
Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy  Julie Wang, MD, Stacie M. Jones,
Prevention of food allergy: Beyond peanut
Risk of oral food challenges
Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract  Anil Nanda, MD, Maeve O'Connor, MD,
Sublingual versus oral immunotherapy for peanut-allergic children: A retrospective comparison  Stacy J. Chin, MD, Brian P. Vickery, MD, Michael D. Kulis,
In vivo effects of glucocorticoids on IgE production
Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens  Riikka Uotila, MD, Anna.
Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity  James N. Francis, PhD, Louisa.
Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy  Brian P. Vickery, MD, Amy M. Scurlock, MD, Michael Kulis,
The natural history of egg allergy in an observational cohort
Safety of epicutaneous immunotherapy for the treatment of peanut allergy: A phase 1 study using the Viaskin patch  Stacie M. Jones, MD, Wence K. Agbotounou,
Eric B. Brandt, PhD, Melissa K. Mingler, MS, Michelle D
Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy  Stacie M. Jones, MD, A.
Macrolide antibiotics and asthma treatment
Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge  Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.
Asthma: The past, future, environment, and costs
The natural history of milk allergy in an observational cohort
Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization  Edwin H. Kim, MD, J. Andrew Bird, MD, Michael Kulis,
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.
Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease  Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,
Natural history of cow’s milk allergy
Modeling asthma exacerbations through lung function in children
Presentation transcript:

A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response  Pooja Varshney, MD, Stacie M. Jones, MD, Amy M. Scurlock, MD, Tamara T. Perry, MD, Alex Kemper, MD, MPH, MS, Pamela Steele, CPNP, Anne Hiegel, RN, Janet Kamilaris, RN, Suzanne Carlisle, RN, Xiaohong Yue, MS, Mike Kulis, PhD, Laurent Pons, PhD, Brian Vickery, MD, A. Wesley Burks, MD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 3, Pages 654-660 (March 2011) DOI: 10.1016/j.jaci.2010.12.1111 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Cumulative amount of peanut protein ingested at OFC by peanut OIT and placebo subjects (*P < .001) after 12 months of therapy. Individual subjects are shown as diamonds (peanut OIT) or squares (placebo); lines designate median values. Journal of Allergy and Clinical Immunology 2011 127, 654-660DOI: (10.1016/j.jaci.2010.12.1111) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Titrated skin prick testing. Change in median wheal size from baseline to time of OFC in peanut OIT and placebo subjects (*P < .001). Boxes represent 25% to 75% quartiles; whiskers represent range. Lines designate median values. Journal of Allergy and Clinical Immunology 2011 127, 654-660DOI: (10.1016/j.jaci.2010.12.1111) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Changes in serum immunoglobulin levels during treatment with peanut OIT and placebo. A, Peanut-specific IgE (*P ≤ .01). B, Peanut-specific IgG (*P < .05). C, Peanut-specific IgG4 (*P ≤ .001). Boxes represent 25% to 75% quartiles; whiskers represent range. Lines designate median values. Journal of Allergy and Clinical Immunology 2011 127, 654-660DOI: (10.1016/j.jaci.2010.12.1111) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Changes in secreted cytokine responses for subjects receiving peanut OIT and placebo. PBMCs were cultured with peanut protein for 72 hours; cytokines were measured via ELISA. A, IL-5 (*P ≤ .02). B, IL-13 (*P ≤ .03). Journal of Allergy and Clinical Immunology 2011 127, 654-660DOI: (10.1016/j.jaci.2010.12.1111) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Change in FoxP3hi: FoxP3intermediate CD4+CD25+ T cells from baseline to time of OFC. PBMCs were stimulated with crude peanut extract and tetanus toxin for 7 days and then stained for Treg markers. Individual subjects are shown for peanut OIT (A) and placebo (B) groups. *P = .04. ns, Not significant. Journal of Allergy and Clinical Immunology 2011 127, 654-660DOI: (10.1016/j.jaci.2010.12.1111) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions