Dynamics under the Telomeric Bridge

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Dynamics under the Telomeric Bridge Sabrina Pisano, Eric Gilson, Marie-Josèphe Giraud-Panis Molecular Cell Volume 68, Issue 4, Pages 643-644 (November 2017) DOI: 10.1016/j.molcel.2017.11.005 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 An Allosteric Structural Transition in S. pombe Poz1 and Human TIN2 Telomeric Proteins Drives the Formation of the Shelterin Complex Fission yeast and human shelterin subcomplexes that are either favored (upper panel) or disfavored (lower panel) by cooperative binding of subunits. For the sake of comparison with the human shelterin, the Taz1-Rap1 subcomplex is depicted as a single building block. The allosteric transition in Poz1 (TIN2) “conformational trigger,” induced by Tpz1 (TPP1) binding, increases Poz1 affinity for Rap1-Taz1 (TRF2), making the assembled protein bridge a more stable entity than individual subcomplexes (upper panel) and decreasing the probability for the existence of the subcomplexes depicted in the lower panels. Molecular Cell 2017 68, 643-644DOI: (10.1016/j.molcel.2017.11.005) Copyright © 2017 Elsevier Inc. Terms and Conditions