An epigenome-wide association study of total serum IgE in Hispanic children Wei Chen, PhD, Ting Wang, PhD, Maria Pino-Yanes, PhD, Erick Forno, MD, MPH,

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Presentation transcript:

An epigenome-wide association study of total serum IgE in Hispanic children Wei Chen, PhD, Ting Wang, PhD, Maria Pino-Yanes, PhD, Erick Forno, MD, MPH, Liming Liang, PhD, Qi Yan, PhD, Donglei Hu, PhD, Daniel E. Weeks, PhD, Andrea Baccarelli, MD, PhD, Edna Acosta-Perez, PhD, Celeste Eng, MS, Yueh-Ying Han, PhD, Nadia Boutaoui, PhD, Catherine Laprise, PhD, Gwyneth A. Davies, MD, Julian M. Hopkin, MD, Miriam F. Moffatt, DPhil, William O.C.M. Cookson, MD, Glorisa Canino, PhD, Esteban G. Burchard, MD, MPH, Juan C. Celedón, MD, DrPH, FAAAAI Journal of Allergy and Clinical Immunology Volume 140, Issue 2, Pages 571-577 (August 2017) DOI: 10.1016/j.jaci.2016.11.030 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Manhattan and QQ plots for results of meta-analyses adjusting for WBC types. The Manhattan plot shows the chromosomal locations of −log10(P value) for association at each CpG site. The solid line illustrates a threshold P value of 2 × 10−7, and the dashed line illustrates a threshold FDR of 0.01. The QQ plot shows observed versus expected −log10(P value) values for association at all loci. The gray area illustrates the 95% confidence band. Journal of Allergy and Clinical Immunology 2017 140, 571-577DOI: (10.1016/j.jaci.2016.11.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Partial regression plots of CpG methylation and total IgE levels for the top 4 genes in the meta-analysis adjusting for WBC types. The x-axis and y-axis, respectively, stand for the residuals of regressing methylation and IgE levels against all other covariates, which are adjusted in the multivariable regressions. Solid and open circles indicate GALA II study and PR-GOAL samples. Journal of Allergy and Clinical Immunology 2017 140, 571-577DOI: (10.1016/j.jaci.2016.11.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2017 140, 571-577DOI: (10.1016/j.jaci.2016.11.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2017 140, 571-577DOI: (10.1016/j.jaci.2016.11.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2017 140, 571-577DOI: (10.1016/j.jaci.2016.11.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology 2017 140, 571-577DOI: (10.1016/j.jaci.2016.11.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Journal of Allergy and Clinical Immunology 2017 140, 571-577DOI: (10.1016/j.jaci.2016.11.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 Journal of Allergy and Clinical Immunology 2017 140, 571-577DOI: (10.1016/j.jaci.2016.11.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E7 Journal of Allergy and Clinical Immunology 2017 140, 571-577DOI: (10.1016/j.jaci.2016.11.030) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions