Association Between Serum Level of Hepatitis B Surface Antigen at End of Entecavir Therapy and Risk of Relapse in E Antigen–Negative Patients Yao-Chun.

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Presentation transcript:

Association Between Serum Level of Hepatitis B Surface Antigen at End of Entecavir Therapy and Risk of Relapse in E Antigen–Negative Patients Yao-Chun Hsu, Lein-Ray Mo, Chi-Yang Chang, Ming-Shiang Wu, Jia-Horng Kao, Wen-Lun Wang, Tzeng-Huey Yang, Chaur-Shine Wang, Ming-Feng Chiang, Chieh-Chang Chen, Yu-Jen Fang, Hsu-Wei Hung, Chun-Ying Wu, Jaw-Town Lin Clinical Gastroenterology and Hepatology Volume 14, Issue 10, Pages 1490-1498.e3 (October 2016) DOI: 10.1016/j.cgh.2016.03.024 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 Significant dose-response association between EOT HBsAg level and clinical (A) and virologic (B) relapse in patients with negative HBeAg at the end of treatment. Clinical Gastroenterology and Hepatology 2016 14, 1490-1498.e3DOI: (10.1016/j.cgh.2016.03.024) Copyright © 2016 AGA Institute Terms and Conditions

Figure 2 Age-adjusted stratified analyses for the association of end-of-therapy HBsAg with clinical (A) and virologic (B) relapses. Clinical Gastroenterology and Hepatology 2016 14, 1490-1498.e3DOI: (10.1016/j.cgh.2016.03.024) Copyright © 2016 AGA Institute Terms and Conditions

Figure 3 HBsAg cutoff set at 10 IU/mL (A for clinical, B for virologic) and 100 IU/mL (C for clinical, D for virologic) to stratify relapse risks. Clinical Gastroenterology and Hepatology 2016 14, 1490-1498.e3DOI: (10.1016/j.cgh.2016.03.024) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 1 Flowchart illustrating identification and enrollment of participants. Clinical Gastroenterology and Hepatology 2016 14, 1490-1498.e3DOI: (10.1016/j.cgh.2016.03.024) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 2 The risk of relapse significantly differed according to HBeAg status at the end of therapy. Panel A (left), clinical relapse; panel B (right), virological relapse. Clinical Gastroenterology and Hepatology 2016 14, 1490-1498.e3DOI: (10.1016/j.cgh.2016.03.024) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 3 Extremely high relapse risks regardless of HBsAg levels in patients who remained HBeAg-positive at the end of therapy. Panel A (left), clinical relapse; panel B (right), virological relapse. Clinical Gastroenterology and Hepatology 2016 14, 1490-1498.e3DOI: (10.1016/j.cgh.2016.03.024) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 4 Age was inversely correlated with HBsAg levels. Clinical Gastroenterology and Hepatology 2016 14, 1490-1498.e3DOI: (10.1016/j.cgh.2016.03.024) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 5 Similar relapse patterns in end-of-therapy HBeAg-negative patients irrespective of their pretreatment HBeAg status. Panel A (left), clinical relapse; panel B (right), virological relapse. Clinical Gastroenterology and Hepatology 2016 14, 1490-1498.e3DOI: (10.1016/j.cgh.2016.03.024) Copyright © 2016 AGA Institute Terms and Conditions