Scurvy in a patient on vemurafenib

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Presentation transcript:

Scurvy in a patient on vemurafenib Meg R. Gerstenblith, MD, Tatyana A. Petukhova, MD, MS, Henry B. Koon, MD JAAD Case Reports Volume 1, Issue 1, Pages 32-33 (January 2015) DOI: 10.1016/j.jdcr.2014.10.008 Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Clinical presentation of scurvy. Perifollicular erythema, keratosis pilaris–like eruption, and corkscrew hairs on the upper back of a patient with vitamin C deficiency receiving vemurafenib for metastatic melanoma (inset with higher magnification of corkscrew hair surrounded by ink dots). JAAD Case Reports 2015 1, 32-33DOI: (10.1016/j.jdcr.2014.10.008) Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histopathologic presentation of scurvy. Punch biopsy of a corkscrew hair shows a hair shaft cut on multiple cross sections with a rare eosinophil underlying the dermis. (Hematoxylin-eosin stain, original magnifications ×4 and inset, ×20.) JAAD Case Reports 2015 1, 32-33DOI: (10.1016/j.jdcr.2014.10.008) Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Resolution of corkscrew hairs and improvement in keratosis pilaris–like eruption after treatment with vitamin C. JAAD Case Reports 2015 1, 32-33DOI: (10.1016/j.jdcr.2014.10.008) Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions