Erin J. Oakley, Gary Van Zant Cell Stem Cell

Slides:

Advertisements

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Advertisements

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Distinct Self-Renewal and Differentiation Phases in the Niche of Infrequently Dividing Hair Follicle Stem Cells Ying V. Zhang, Janice Cheong, Nichita Ciapurin,

Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair Francesco S. Loffredo, Matthew L. Steinhauser,

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle Isabel Beerman, Jun Seita, Matthew A.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Age-associated changes in human hematopoietic stem cells

Dysfunctional Niches as a Root of Hematopoietic Malignancy

Back to 2D Culture for Ground State of Intestinal Stem Cells

Martin Wahlestedt, David Bryder Cell Stem Cell

Finding Shangri-La: Limiting the Impact of Senescence on Aging

9-1-1: HSCs Respond to Emergency Calls

Volume 1, Issue 1, Pages (June 2007)

Cell Cycle Rules Pluripotency

Adipocytes at the Core of Bone Function

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

In Search of Human Hematopoietic Stem Cell Identity

A Path to Insulin Independence: “The End of the Beginning”

Patterning Stem Cell Differentiation

Volume 9, Issue 2, Pages (August 2011)

Volume 16, Issue 6, Pages (June 2015)

Christopher Hine, James R. Mitchell Cell Stem Cell

Gerry P. Crossan, Juan I. Garaycoechea, Ketan J. Patel Cell Stem Cell

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way

Public Private Partnerships: A Marriage of Necessity

Christopher Hine, James R. Mitchell Cell Stem Cell

Maintaining Hematopoietic Stem Cells in the Vascular Niche

Stressed-Out HSCs Turn Up p38α and Purine to Proliferate

A New Image of the Hematopoietic Stem Cell Vascular Niche

Revealing the Hidden Powers that Fuel Adult Neurogenesis

Stem Cell Therapies in Clinical Trials: Progress and Challenges

Stem Cell Aging and Sex: Are We Missing Something?

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

Dysfunctional Niches as a Root of Hematopoietic Malignancy

Volume 18, Issue 2, Pages (February 2016)

Tim Willinger, Richard A. Flavell Cell Stem Cell

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

A Coated Sponge: Toward Neonatal Brain Repair

Meddling with METTLs in Normal and Leukemia Stem Cells

Aspp1: A Guardian of Hematopoietic Stem Cell Integrity

Making HSCs on Demand: Looking Ahead

Volume 6, Issue 3, Pages (March 2010)

NO Signals from the Cancer Stem Cell Niche

Direct Conversion Provides Old Neurons from Aged Donor’s Skin

Volume 121, Issue 6, Pages (June 2005)

Disrupting the Stem Cell Niche: Good Seeds in Bad Soil

Monica L. Guzman, Craig T. Jordan Cancer Cell

The Hidden Memory of Differentiating Cells

Maintaining Hematopoietic Stem Cells in the Vascular Niche

Simón Méndez-Ferrer, María García-Fernández, Carlos L.F. de Castillejo

Chapter 29 - Stem Cells and Generation of New Cells in the

Aging Stem Cells: Transcriptome Meets Epigenome Meets Methylome

Volume 13, Issue 2, Pages (August 2013)

Mesp1 at the Heart of Mesoderm Lineage Specification

Special Stem Cells for Bone

Volume 13, Issue 4, Pages (April 2008)

In Search of Human Hematopoietic Stem Cell Identity

Rejuvenation: It’s in Our Blood

Cellular Alchemy and the Golden Age of Reprogramming

Young at Heart Cell Volume 153, Issue 4, Pages (May 2013)

Knocking the Wnt out of the Sails of Leukemia Stem Cell Development

Presentation transcript:

Age-Related Changes in Niche Cells Influence Hematopoietic Stem Cell Function Erin J. Oakley, Gary Van Zant Cell Stem Cell Volume 6, Issue 2, Pages 93-94 (February 2010) DOI: 10.1016/j.stem.2010.01.008 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Heterochronic Parabiosis Rejuvenates HSC Function In aged mice (top), HSCs accumulate but exhibit skewed patterns of differentiation, favoring more production of myeloid cells at the expense of B lymphocytes. This effect is at least partially mediated by osteoblast niche cell production of IGF-1. When exposed to soluble factors from young mice (bottom), the impact of IGF-1 is overcome, HSC accumulation is dampened, and the ratio of B cell: myeloid cell production is recovered. Cell Stem Cell 2010 6, 93-94DOI: (10.1016/j.stem.2010.01.008) Copyright © 2010 Elsevier Inc. Terms and Conditions