Shannon M. Kahan, Allan J. Zajac Immunity

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Presentation transcript:

A Stay of Execution: Type I Interferons Pardon T Cells from Death by Natural Killers Shannon M. Kahan, Allan J. Zajac Immunity Volume 40, Issue 6, Pages 861-862 (June 2014) DOI: 10.1016/j.immuni.2014.05.009 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Type I IFN Signaling Protects Activated T Cells from NK-Cell-Mediated Death Type I IFN signals to antigen-activated T cells reduce the expression of NK cell activatory ligands and elevates the levels of inhibitory ligands, rendering the responding T cell resistant to NK cell attack. Without type I IFN signals, activated T cells can be targeted by perforin-dependent NK cell killing. Immunity 2014 40, 861-862DOI: (10.1016/j.immuni.2014.05.009) Copyright © 2014 Elsevier Inc. Terms and Conditions