Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity Steven L. Young Reproductive BioMedicine.

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Presentation transcript:

Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity Steven L. Young Reproductive BioMedicine Online Volume 27, Issue 5, Pages 497-505 (November 2013) DOI: 10.1016/j.rbmo.2013.06.010 Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Classical actions of nuclear oestrogen and progesterone receptors. (a) Steroid receptors bind steroid and then bind cognate DNA sequences. (b) Non-steroidal ligands can also act through nuclear steroid receptors. co=co-regulator; HRE=hormone response element; n=nuclear steroid receptor monomer; ns=non-steroid; p=RNA polymerase; s=steroid. Reproductive BioMedicine Online 2013 27, 497-505DOI: (10.1016/j.rbmo.2013.06.010) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Non-classical actions of nuclear oestrogen and progesterone receptors. (a) Membrane-associated steroid receptors, either isoforms of classical receptors, or (b) unrelated transmembrane receptors recognize steroid hormones and initiate a cytoplasmic signalling cascade. (c) Growth factors signalling can act by causing post-translational modifications of nuclear steroid receptors. (d) Additionally, oestrogen and progesterone can modulate expression by altering mRNA turnover and translation. (e) Alternatively, steroids can bind classical nuclear receptors, which act by binding other proteins rather than DNA. co=co-regulator; G=growth factor; HRE=hormone response element; n=nuclear steroid receptor monomer; ns=non-steroid; p=RNA polymerase; s=steroid; TF=transcription factor. Reproductive BioMedicine Online 2013 27, 497-505DOI: (10.1016/j.rbmo.2013.06.010) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Protocol for modelled cycles (adapted from Usadi et al., 2008). Reproductive BioMedicine Online 2013 27, 497-505DOI: (10.1016/j.rbmo.2013.06.010) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions