Main branch restenosis at 1 year DKCRUSH-VI Trial design: Patients with Medina 1,1,1 and 0,1,1 coronary bifurcation lesions undergoing stenting with a provisional side branch (SB) approach were randomly assigned in a 1:1 fashion to angiography-guided or FFR-guided groups. Patients were followed for 1 year. Results (p = 0.01) Side branch stenting in angiography vs. FFR arms: 38.1% vs. 25.9% (p = 0.01) In-segment restenosis in distal main vessel: 9.2% vs. 1.7%, p = 0.01; side branch vessel restenosis: 21.2% vs. 11.8%, p = 0.037 MACE: 18.1% vs. 18.1%, p = 1.0; MI: 13.8% vs. 11.9%, p = 0.74; TLR: 5.0% vs. 3.1%, p = 0.57; stent thrombosis: 1.3% vs. 0.6%, p > 0.05 % Conclusions FFR-guided strategy results in fewer stents and less angiographic restenosis than an angiography alone strategy in true bifurcation lesions where a provisional SB approach is pursued Clinical outcomes at 1 year were similar Appears to be a reasonable approach to ↓ stenting due to occulostenotic reflex in bifurcation lesions Main branch restenosis at 1 year Angiography-guided (n = 160) FFR- guided (n = 160) Presented by Dr. Shao Liang Chen at TCT 2014