The reward system in addiction

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Presentation transcript:

The reward system in addiction Role in associative learning and craving

The reward system in addiction Drugs: Stimulants Nicotine Alcohol Marihuana Others Nucleus Accumbens (NAc) Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3), 341-350.

The reward system in addiction Drug = reward Drugs: Stimulants Nicotine Alcohol Marihuana Others Nucleus Accumbens (NAc) Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3), 341-350.

Reward pathways: mesolimbic Mesolimbic pathway Nucleus Accumbens (NAc) Ventral Tegmental Area Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3), 341-350.

Reward pathway: mesocortical Prefrontal Cortex Ventral Tegmental Area Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3), 341-350.

Associative learning and craving

Incentive-based learning Reward Incentive-based learning Goal-directed behaviors Nutt, D. & Nestor, L. (2013). Addiction. Oxford New York, NY: Oxford University Press.

Associative learning and conditioning Reward Associative learning and conditioning Nutt, D. & Nestor, L. (2013). Addiction. Oxford New York, NY: Oxford University Press.

Associative learning and drug craving Environmental stimuli Reinforcer Conditioned stimuli Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.

Associative learning and drug craving Neutral stimuli Places People Mood state Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.

Associative learning and drug craving Neutral stimuli Places People Mood state Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.

Associative learning and drug craving Conditioned stimuli Places People Mood state Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.

Associative learning and drug craving Conditioned stimuli Craving Places People Mood state Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.