Miliary Mesothelioma: A New Clinical and Radiological Presentation in Mesothelioma Patients with Prolonged Survival After Trimodality Therapy Lesek Purek,

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Miliary Mesothelioma: A New Clinical and Radiological Presentation in Mesothelioma Patients with Prolonged Survival After Trimodality Therapy Lesek Purek, MD, Sophie Laroumagne, MD, Hervé Dutau, MD, Fabien Maldonado, MD, Philippe Astoul, MD, PhD Journal of Thoracic Oncology Volume 6, Issue 10, Pages 1753-1756 (October 2011) DOI: 10.1097/JTO.0b013e31822e295a Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Case 1: Computed tomography of the chest showing diffuse parenchymal nodularity on the remaining lung, lymphangitis, and pleural effusion. Journal of Thoracic Oncology 2011 6, 1753-1756DOI: (10.1097/JTO.0b013e31822e295a) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Endobronchial ultrasound biopsies at the time of recurrence. A, Representative image of diffuse tubulopapillary proliferation of mesothelial origin with invasion of the adipose tissue. B, Immunohistochemical staining-diffuse cytoplasmic and nuclear staining with anticalretinin of mesothelial cells. Few cells are observed between adipocytes (magnification ×400). C, Tubular architecture. Mesothelial cells are cuboid with central round nuclei without mitosis (hematoxylin & eosin stain, magnification ×400). Journal of Thoracic Oncology 2011 6, 1753-1756DOI: (10.1097/JTO.0b013e31822e295a) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Case 2: Computed tomography scan of the chest at admission (November 2010) showing multiple nodules on the left lung. Journal of Thoracic Oncology 2011 6, 1753-1756DOI: (10.1097/JTO.0b013e31822e295a) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Case 2: Computed tomography scan of the chest 3 months (May 10, 2011) after the last cycle of chemotherapy (six cycles). Spectacular improvement of the chest imaging with complete response. Journal of Thoracic Oncology 2011 6, 1753-1756DOI: (10.1097/JTO.0b013e31822e295a) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions