Cetuximab treatment increases IFNγ receptor 1 expression.

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Figure 3 Decreased AHI1 in human CD4+ T cells is associated with decreased proliferation and increased IFNγ production Decreased AHI1 in human CD4+ T cells.

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Cetuximab treatment increases IFNγ receptor 1 expression. Cetuximab treatment increases IFNγ receptor 1 expression. A and B, JHU-029, PCI-15B, JHU-028, JHU-022, EGFR+ HNC cells, and MCF-7 EGFRlow/− breast cancer cells were incubated with cetuximab (10 μg/mL, 72 hours), and levels of IFNγ receptor α chain (CD119). A and C, EGFR expression were determined by FACS. Results represent mean ± SEM from three independent experiments; *, P ≤ 0.05; ***, P ≤ 0.0001). MFI, mean fluorescence intensity. Raghvendra M. Srivastava et al. Cancer Immunol Res 2015;3:936-945 ©2015 by American Association for Cancer Research