Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40 Jose L. Gomez, MD, MS, Gina M. Crisafi,

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Presentation transcript:

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40 Jose L. Gomez, MD, MS, Gina M. Crisafi, BS, Carole T. Holm, RN, Deborah A. Meyers, PhD, Gregory A. Hawkins, PhD, Eugene R. Bleecker, MD, Nizar Jarjour, MD, Lauren Cohn, MD, Geoffrey L. Chupp, MD Journal of Allergy and Clinical Immunology Volume 136, Issue 1, Pages 51-58.e10 (July 2015) DOI: 10.1016/j.jaci.2014.11.027 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Haplotype map for the CHI3L1 gene in subjects of EA from YCAAD and SARP. Journal of Allergy and Clinical Immunology 2015 136, 51-58.e10DOI: (10.1016/j.jaci.2014.11.027) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 The A allele of rs12141494 in subjects of EA with asthma is associated with increased asthma severity (A), higher serum YKL-40 levels (B), and worse airflow obstruction (C). Journal of Allergy and Clinical Immunology 2015 136, 51-58.e10DOI: (10.1016/j.jaci.2014.11.027) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 The rs12141494 AA genotype in subjects of EA with asthma is associated with higher YKL-40 sputum levels. Journal of Allergy and Clinical Immunology 2015 136, 51-58.e10DOI: (10.1016/j.jaci.2014.11.027) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Haplotype maps for the CHI3L1 gene in subjects of AA in YCAAD and SARP (A), Utah residents with Northern and Western European Ancestry from the CEPH collection HapMap (B), and African ancestry in the Southwest United States HapMap (C). Journal of Allergy and Clinical Immunology 2015 136, 51-58.e10DOI: (10.1016/j.jaci.2014.11.027) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Variation in the promoter SNP rs4950928 in the CHI3L1 gene and effect in YKL-40 protein levels in subjects of EA in YCAAD (A) and SARP (B). Journal of Allergy and Clinical Immunology 2015 136, 51-58.e10DOI: (10.1016/j.jaci.2014.11.027) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 rs12141494 and airflow obstruction in subjects of EA in YCAAD (A) and SARP (B). Journal of Allergy and Clinical Immunology 2015 136, 51-58.e10DOI: (10.1016/j.jaci.2014.11.027) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions