Impact of phenylephrine administration on cerebral tissue oxygen saturation and blood volume is modulated by carbon dioxide in anaesthetized patients†

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Impact of phenylephrine administration on cerebral tissue oxygen saturation and blood volume is modulated by carbon dioxide in anaesthetized patients† L. Meng, A.W. Gelb, B.S. Alexander, A.E. Cerussi, B.J. Tromberg, Z. Yu, W.W. Mantulin British Journal of Anaesthesia Volume 108, Issue 5, Pages 815-822 (May 2012) DOI: 10.1093/bja/aes023 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Study protocol. E′CO2, end-tidal carbon dioxide. British Journal of Anaesthesia 2012 108, 815-822DOI: (10.1093/bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 Pearson's correlation between changes in cerebral tissue oxygen saturation ( Δ Sct O 2 ) and changes in CBV (ΔCBV). British Journal of Anaesthesia 2012 108, 815-822DOI: (10.1093/bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 (a) Cerebral tissue oxygen saturation ( Sct O 2 ) and (b) CBV changes (Δ) during hypocapnia, normocapnia, and hypercapnia. British Journal of Anaesthesia 2012 108, 815-822DOI: (10.1093/bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions

Fig 4 Hypothetical explanation of how phenylephrine treatment induces cerebral autoregulatory vasoconstriction. CSA, cross-sectional area; MAP, mean arterial pressure; CPP, cerebral perfusion pressure; CBF, cerebral blood flow. British Journal of Anaesthesia 2012 108, 815-822DOI: (10.1093/bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions

Fig 5 FD-NIRS measurements of THC (top panel), cerebral tissue oxygen saturation (second panel), oxy-haemoglobin concentration (third panel), and deoxy-haemoglobin concentration (bottom panel) during right external carotid artery clamping (a) and right internal carotid artery clamping (b) in a patient with defective collateral circulation through the Circle of Willis. Note that the time scales (s) are different between (a) and (b). (Courtesy of Fady T. Charbel, MD, FACS.) British Journal of Anaesthesia 2012 108, 815-822DOI: (10.1093/bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions