Standard step sectioning of skin biopsy specimens diagnosed as superficial basal cell carcinoma frequently yields deeper and more aggressive subtypes

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Presentation transcript:

Standard step sectioning of skin biopsy specimens diagnosed as superficial basal cell carcinoma frequently yields deeper and more aggressive subtypes Kim P. Nguyen, MD, G. Jimmy Knuiman, MD, Piet E.J. van Erp, PhD, Willeke A. Blokx, MD, PhD, Malou Peppelman, PhD, Marie-Jeanne P. Gerritsen, MD, PhD Journal of the American Academy of Dermatology Volume 76, Issue 2, Pages 351-353.e3 (February 2017) DOI: 10.1016/j.jaad.2016.09.028 Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Histopathological examination method of a punch biopsy specimen suspicious for basal cell carcinoma. Schematic overview of the histopathological examination process. The dimensions of the punch biopsy specimen might be smaller than depicted in this figure because of shrinkage after formalin fixation and histologic processing, embedding, and mounting. X: These sections are stained with hematoxylin-eosin and used for histopathological examination. In the initial sections it is unknown which slices are stained and examined. Journal of the American Academy of Dermatology 2017 76, 351-353.e3DOI: (10.1016/j.jaad.2016.09.028) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Supplemental Fig 1 Detection of various basal cell carcinoma subtypes and adnexal extension in hematoxylin-eosin-stained sections. A, Superficial component in the initial section of punch biopsy specimen 24 (Supplemental Table II). B to E, In the additional sections of the same punch biopsy specimen (micro-) nodular and infiltrative subtypes are detected. F, Some lesions showed an adnexal extension (arrow). (Original magnification: ×5.) Journal of the American Academy of Dermatology 2017 76, 351-353.e3DOI: (10.1016/j.jaad.2016.09.028) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions