Volume 138, Issue 4, Pages 1514-1524 (April 2010) Defining the Role of Cholecystokinin in the Lipid-Induced Human Brain Activation Matrix  Daniel J. Lassman, Shane McKie, Lloyd J. Gregory, Simon Lal, Massimo D'Amato, Islay Steele, Andrea Varro, Graham J. Dockray, Steven C.R. Williams, David George Thompson  Gastroenterology  Volume 138, Issue 4, Pages 1514-1524 (April 2010) DOI: 10.1053/j.gastro.2009.12.060 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Brain areas activated in both studies by lipid compared with saline infusion are shown for the left and right brain. Conjunction analysis threshold at Punc < .005 for display purposes. Cb, cerebellum; Med, medulla; Pons, pons; Hypo, hypothalamus; Caud, caudate, and MC, motor cortex. Gastroenterology 2010 138, 1514-1524DOI: (10.1053/j.gastro.2009.12.060) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 The average time course (percentage of BOLD signal change from baseline per minute) and area under the curve (AUC) plots in a 10-mm radius sphere for each condition in study 2 (A) Medulla, (B) pons, (C) hypothalamus, (D) motor cortex, (E) cerebellum. ***P < .001, **P < .01, *P < .05 compared with lipid/inactive AUC. Gastroenterology 2010 138, 1514-1524DOI: (10.1053/j.gastro.2009.12.060) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 Changes in gallbladder size are shown before and after intragastric infusion of lipid and saline with dexloxiglumide and inactive treatment. (A) Axial abdominal MR images show the gallbladder in the 4 experimental conditions in 1 subject. The gallbladder (marked by the arrow in first 2 images) was seen to decrease in size only after infusion of lipid with inactive treatment. (B) Group data for the median, lower, and upper quartiles plus range, of change in gallbladder volume, in each of the 4 experimental conditions. Gastroenterology 2010 138, 1514-1524DOI: (10.1053/j.gastro.2009.12.060) Copyright © 2010 AGA Institute Terms and Conditions