High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant Jianhui Liu,

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(RFLP Electrophoresis)

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Manipulation of DNA. Restriction enzymes are used to cut DNA into smaller fragments. Different restriction enzymes recognize and cut different DNA sequences.

(RFLP Electrophoresis)

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High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant Jianhui Liu, MD, Kunimasa Yagi, MD, PhD, Atsushi Nohara, MD, PhD, Daisuke Chujo, MD, PhD, Azusa Ohbatake, MD, Aya Fujimoto, MD, Yukiko Miyamoto, MD, Junji Kobayashi, MD, PhD, Masakazu Yamagishi, MD, PhD Journal of Clinical Lipidology Volume 12, Issue 2, Pages 331-337 (March 2018) DOI: 10.1016/j.jacl.2017.12.011 Copyright © 2017 National Lipid Association Terms and Conditions

Figure 1 Agarose electrophoresis showing the ANGPTL8 R59W variant analyzed by PCR-RFLP. DNA samples were digested with restriction enzyme FokI and the resulting restriction fragments are separated according to their lengths by gel electrophoresis. ANGPTL8, angiopoietin-like protein 8; Hom, homozygote; Het, heterozygote; PCR-RFLP, polymerase chain reaction–restriction fragment length polymorphism; Wild, wild type. Journal of Clinical Lipidology 2018 12, 331-337DOI: (10.1016/j.jacl.2017.12.011) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 2 LDLC/HDLC ratio in IGT subjects. Ratio of LDL-C to HDL-C was compared between the subjects with wild-type RR and those with heterozygote RW and homozygote WW forms of the ANGPTL8 Rs.2278426 variants in 37 IGT subjects. ANGPTL8, angiopoietin-like protein 8; IGT, impaired glucose tolerance; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; RR, ANGPTL8 R59W wild type; RW, ANGPTL8 R59W heterozygote; WW, ANGPTL8 R59W homozygote. Journal of Clinical Lipidology 2018 12, 331-337DOI: (10.1016/j.jacl.2017.12.011) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 3 Onset age of non-obese diabetes subjects. (A) Onset age of T2D mellitus was compared between the subjects with wild-type RR and those with heterozygote RW and homozygote WW forms of the ANGPTL8 Rs.2278426 variants in 88 nonobese diabetes subjects. (B) Onset age of T2D mellitus was compared between the subjects with heterozygote RW and homozygote WW forms of the ANGPTL8 Rs.2278426 variants in 47 non-obese diabetes subjects. ANGPTL8, angiopoietin-like protein 8; T2D, type 2 diabetes; RR, ANGPTL8 R59W wild type; RW, ANGPTL8 R59W heterozygote; WW, ANGPTL8 R59W homozygote. Journal of Clinical Lipidology 2018 12, 331-337DOI: (10.1016/j.jacl.2017.12.011) Copyright © 2017 National Lipid Association Terms and Conditions