CIS595: Lecture 5 Acknowledgement:

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URL: http://www.smi.stanford.edu/projects/helix/bmi214/ CIS595: Lecture 5 Acknowledgement: Red Slides are taken from Russ Altman’s BMI 214: Representations and Algorithms for Computational Molecular Biology URL: http://www.smi.stanford.edu/projects/helix/bmi214/

Find all pairwise alignments between nodes; Build a guide tree; Align sequences following a guide tree: Merge the best pair; Continue until the root node is reached Alternative: Find all alignments of the merged pair with the other nodes; Merge the best nodes

How to apply dynamic programming on the profiles: Show an example