Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis

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Presentation transcript:

Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis Teet Pullerits, MD, PhDa, Lea Praks, MD, PhDb, Vahur Ristioja, MDc, Jan Lötvall, MD, PhDa Journal of Allergy and Clinical Immunology Volume 109, Issue 6, Pages 949-955 (June 2002) DOI: 10.1067/mai.2002.124467 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Study design and grass pollen counts in the study area. Journal of Allergy and Clinical Immunology 2002 109, 949-955DOI: (10.1067/mai.2002.124467) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Mean daytime (left panel) and nighttime (right panel) symptom scores in patients with grass pollen-induced allergic rhinitis treated for 50 days with FPANS (200 μg/d), montelukast (ML ; 10 mg/d), a combination of montelukast and loratadine (ML+LT ; 10 mg/d), or placebo. Journal of Allergy and Clinical Immunology 2002 109, 949-955DOI: (10.1067/mai.2002.124467) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 Mean symptom score for nasal blockage, sneezing, rhinorrhea, and nasal itching in patients with allergic rhinitis treated with FPANS, montelukast (ML) , a combination of montelukast and loratadine (ML+LT) , or placebo (*P < .05). Journal of Allergy and Clinical Immunology 2002 109, 949-955DOI: (10.1067/mai.2002.124467) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 4 The grass pollen-induced change (means ± SEMs) in the number of EG2+ epithelial and subepithelial eosinophils per square millimeter (EOS/sqmm) in nasal biopsy specimens of patients with allergic rhinitis treated with FPANS, montelukast (ML) , a combination of montelukast and loratadine (ML+LT) , or placebo (*P < .05). Journal of Allergy and Clinical Immunology 2002 109, 949-955DOI: (10.1067/mai.2002.124467) Copyright © 2002 Mosby, Inc. Terms and Conditions