Volume 26, Issue 1, Pages 6-7 (July 2017)

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Volume 26, Issue 1, Pages 6-7 (July 2017) Will Gut Microbiota Help Design the Next Generation of GLP-1-Based Therapies for Type 2 Diabetes? Sandrine Paule Claus Cell Metabolism Volume 26, Issue 1, Pages 6-7 (July 2017) DOI: 10.1016/j.cmet.2017.06.009 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Regulation of GLP-1 Sensitivity by Gut Microbiota In the presence of a dysbiotic gut microbiota, the mRNA expression of the GLP-1 receptor (GLP1R) and of the neuronal nitric oxide synthase (nNOS) are downregulated in enteric neurons, thereby reducing NO production and downstream stimulation of the afferent vagus nerve. In the absence of such stimulation, the physiological effects of GLP-1 depending on a functional gut-brain axis, gastric emptying, and insulin secretion are impaired. Cell Metabolism 2017 26, 6-7DOI: (10.1016/j.cmet.2017.06.009) Copyright © 2017 Elsevier Inc. Terms and Conditions