Genomewide Significant Linkage to Migrainous Headache on Chromosome 5q21  Dale R. Nyholt, Katherine I. Morley, Manuel A.R. Ferreira, Sarah E. Medland, Dorret I. Boomsma, Andrew C. Heath, Kathleen R. Merikangas, Grant W. Montgomery, Nicholas G. Martin  The American Journal of Human Genetics  Volume 77, Issue 3, Pages 500-512 (September 2005) DOI: 10.1086/444510 Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 1 Profile plot for the three symptomatic classes (CL1, CL2, and CL3) under the four-class model. Endorsement probabilities indicate the proportion of individuals in each class presenting with each symptom. All endorsement probabilities for CL0 were <0.005 (data not shown). Descriptions of symptom abbreviations are given in table 2. The American Journal of Human Genetics 2005 77, 500-512DOI: (10.1086/444510) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 2 Results of SOLAR genomewide multipoint linkage analysis for LCA migraine, showing thresholds for nominal P=.01 (dash-dot-dot line) and P=.05 (dotted line). The American Journal of Human Genetics 2005 77, 500-512DOI: (10.1086/444510) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 3 Results of MERLIN-regress genomewide multipoint linkage analysis for LCA migraine, showing thresholds obtained via simulation for significant linkage (dashed line) and suggestive linkage (dash-dot line). Thresholds estimated via linear regression for nominal P=.01 (dash-dot-dot line) and P=.05 (dotted line) are also displayed. The American Journal of Human Genetics 2005 77, 500-512DOI: (10.1086/444510) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 4 Results of MERLIN-regress chromosome-specific multipoint linkage analysis for LCA migraine and subphenotypes reaching nominal P≤.05. The American Journal of Human Genetics 2005 77, 500-512DOI: (10.1086/444510) Copyright © 2005 The American Society of Human Genetics Terms and Conditions