Locomotor activity is variable and uncoordinated in Nes-Cre; Wt1fl/fl pups. Locomotor activity is variable and uncoordinated in Nes-Cre; Wt1fl/fl pups.

Slides:

Advertisements

Similar presentations

Prostaglandin E2 (PGE2) induces no significant alteration in circadian locomotor activity. Prostaglandin E2 (PGE2) induces no significant alteration in.

Advertisements

Reduced astrocyte proliferation results in increased immune cell infiltration into the injured GM Reduced astrocyte proliferation results in increased.

Volume 93, Issue 2, Pages (January 2017)

Volume 87, Issue 1, Pages (July 2015)

Volume 95, Issue 2, Pages e6 (July 2017)

Spiral Wave Dynamics in Neocortex

Effects of Multijoint Spastic Reflexes of the Legs During Assisted Bilateral Hip Oscillations in Human Spinal Cord Injury Tanya Onushko, MS, Allison.

Volume 46, Issue 1, Pages (April 2005)

Volume 95, Issue 2, Pages e6 (July 2017)

Chenguang Zheng, Kevin Wood Bieri, Yi-Tse Hsiao, Laura Lee Colgin

M. Victoria Puig, Earl K. Miller Neuron

Increased astrocyte proliferation is paralleled with reduced infiltration of immune cells in mice with inducible SMOM2 expression in astrocytes at 5 dpi.

Volume 45, Issue 1, Pages (January 2005)

Volume 89, Issue 6, Pages (March 2016)

Short-Term Memory of Motor Network Performance via Activity-Dependent Potentiation of Na+/K+ Pump Function Hong-Yan Zhang, Keith T. Sillar Current Biology

Modeling of an isolated rhythm-generating population.

Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity Avishek.

Phenotypic Characterization of Speed-Associated Gait Changes in Mice Reveals Modular Organization of Locomotor Networks Carmelo Bellardita, Ole Kiehn

CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation Joshua P.

Network Modularity: Back to the Future in Motor Control

Volume 72, Issue 4, Pages (November 2011)

Innervation of Wt1+ neurons and number of commissural neurons in neonatal mice. Innervation of Wt1+ neurons and number of commissural neurons in neonatal.

Volume 93, Issue 2, Pages (January 2017)

New Experiences Enhance Coordinated Neural Activity in the Hippocampus

Volume 16, Issue 4, Pages (July 2016)

Volume 24, Issue 6, Pages (March 2014)

Theta Oscillations during Active Sleep Synchronize the Developing Rubro-Hippocampal Sensorimotor Network Carlos Del Rio-Bermudez, Jangjin Kim, Greta.

Spike Timing-Dependent LTP/LTD Mediates Visual Experience-Dependent Plasticity in a Developing Retinotectal System Yangling Mu, Mu-ming Poo Neuron

Volume 75, Issue 5, Pages (September 2012)

Daisuke Satoh, Christiane Pudenz, Silvia Arber Neuron

Fig. 1. Neurobehavioral testing in YG8R mice transplanted with wild-type mouse HSPCs. Neurobehavioral testing in YG8R mice transplanted with wild-type.

Volume 87, Issue 5, Pages (September 2015)

The Spinal Cord Has an Intrinsic System for the Control of pH

Ana Parabucki, Ilan Lampl Cell Reports

Volume 60, Issue 4, Pages (November 2008)

Volume 23, Issue 10, Pages (May 2013)

TrkB-T1 is upregulated in cerebellum of Pex14ΔC/ΔC BL/ICR mouse at P3.

Serial, Covert Shifts of Attention during Visual Search Are Reflected by the Frontal Eye Fields and Correlated with Population Oscillations Timothy J.

Network Modularity: Back to the Future in Motor Control

Xiaomo Chen, Marc Zirnsak, Tirin Moore Cell Reports

Shox2+ neurons and two types of V2a (Chx10+) cells.

Mice with Wt1 inactivation display altered locomotion.

Timing, Timing, Timing: Fast Decoding of Object Information from Intracranial Field Potentials in Human Visual Cortex Hesheng Liu, Yigal Agam, Joseph.

A, Multivariate glm analysis for the aggregate observer (for the interval range within –450 and 250 ms from action execution). A, Multivariate glm analysis.

Volume 76, Issue 4, Pages (November 2012)

Volume 23, Issue 10, Pages (May 2013)

LFA-1 is present in cytosolic clusters similar to those containing RhoB and tubulin in migrating T lymphocytes, and reducing RhoB abundance impairs the.

Translaminar Cortical Membrane Potential Synchrony in Behaving Mice

Functional networks of proteins associated with SL3a, SL3abc, SL123, and D3 transcripts. Functional networks of proteins associated with SL3a, SL3abc,

Self-Generated Movements with “Unexpected” Sensory Consequences

Volume 28, Issue 8, Pages e3 (April 2018)

Bálint Lasztóczi, Thomas Klausberger Neuron

Neuronal ensembles in optic tectum microcircuits.

Ian C. Fiebelkorn, Yuri B. Saalmann, Sabine Kastner Current Biology

A Gradient in Synaptic Strength and Plasticity among Motoneurons Provides a Peripheral Mechanism for Locomotor Control Wei-Chun Wang, Paul Brehm Current.

Commissural Wt1+ neurons.

P2X4R blockade increases pro‐inflammatory gene expression after EAE

Volume 90, Issue 4, Pages (May 2016)

V-SVZ cultures express transcription factors expected for region of origin. V-SVZ cultures express transcription factors expected for region of origin.

Transcription factors defining dorsal or ventral identity are differentially expressed in dorsal and ventral hamartomas in TSC. Transcription factors defining.

Altered oligodendrocyte progenitor cell (OPC) marker protein expression in two white matter regions of ShhΔFP/ΔFP and SmoΔNT/ΔNT embryos at E15.5. Altered.

Volume 9, Pages (November 2018)

Recordings from brainstem-spinal cord preparation and GABA content in the brain. Recordings from brainstem-spinal cord preparation and GABA content in.

Left–right alternation is disrupted in the absence of WT1 cell function. Left–right alternation is disrupted in the absence of WT1 cell function. A, Cre.

Expression of p130CAS in primary culture neurons

Volume 33, Issue 4, Pages (February 2002)

Elimination of dendritic spines per 2 d.

Binocular neurons mismatched in spatial frequency are also mismatched in orientation preference. Binocular neurons mismatched in spatial frequency are.

Dynamics of CREB hot spots in the nuclei of living cortical neurons.

Volume 42, Issue 3, Pages (May 2004)

Presentation transcript:

Locomotor activity is variable and uncoordinated in Nes-Cre; Wt1fl/fl pups. Locomotor activity is variable and uncoordinated in Nes-Cre; Wt1fl/fl pups. (A) Representative traces showing locomotor-like activity during fictive locomotion from left and right lumbar (L) 2 and right L5 ventral roots from control (Nes-Cre;Wt1+/+) and Wt1 conditional knockout (Nes-Cre;Wt1fl/fl) mice. Rhythmic activity was induced by application of NMDA, serotonin, and dopamine. Raw traces in black; rectified, low-pass filtered signal of lL2 trace in blue; activity burst shown in green. Spinal cord schematic depicts the attached suction electrodes to the right (r) and left (l) L2 and rL5 ventral roots. Scale bar: 5 s. (B) Phase analysis and associated coherence power spectra of left/right (L2/L2) and flexor/extensor (L2/L5) recordings. Regions of persistent coherence emerge for control mice at 0.30 Hz, whereas spinal cords from Nes-Cre;Wt1fl/fl mice show an intermittent coherence region at 0.18 Hz. Color-graded scale indicates normalized coherence. Scale bar: 125 s. (C) Locomotor patterns, analyzed from 20 consecutive bursts, reveal impaired and variable left/right and flexor/extensor alternation in Nes-Cre;Wt1fl/fl mice (black dots). Normal left/right and flexor/extensor alternation is maintained in control (white dots) mice. Each dot represents one cord; arrows represent the mean phase. The length of the vector is a measure of the statistical significance of the preferred phase; dashed grey line indicates regions of significance and high significance at 0.5 and 0.8, respectively (Rayleigh test and Watson's U2 test). n = 5 pups (control); n = 7 pups (Nes-Cre;Wt1fl/fl). (D)Nes-Cre;Wt1fl/fl mice have a slower locomotor frequency than control mice. Data are shown as mean ± SD. n = 5 pups (control); n = 7 pups (Nes-Cre;Wt1fl/fl). Significance was tested using two-tailed Mann–Whitney U test. (E, F) The slower locomotor frequency in Nes-Cre;Wt1fl/fl mice is mirrored by an increased cycle period, and burst and interburst duration in both L2 (E) and L5 (F) roots. Data are shown as mean ± SD. n = 5 pups (control); n = 7 pups (Nes-Cre;Wt1fl/fl). Significance was tested using two-tailed Mann–Whitney U test. Significance level: **P < 0.01, ***P < 0.001. Danny Schnerwitzki et al. LSA 2018;1:e201800106 © 2018 Schnerwitzki et al.