Dr. Maryam Tajvar Department of Health Management and Economics

Slides:

Advertisements

Similar presentations

Katrina Abuabara, MD, MA1 Esther E Freeman MD, PhD2;

Advertisements

What is a review? An article which looks at a question or subject and seeks to summarise and bring together evidence on a health topic.

Postgraduate Course 7. Evidence-based management: Research designs.

Systematic Reviews Dr Sharon Mickan Centre for Evidence-based Medicine

The Bahrain Branch of the UK Cochrane Centre In Collaboration with Reyada Training & Management Consultancy, Dubai-UAE Cochrane Collaboration and Systematic.

Secondary Data Analysis: Systematic Reviews & Associated Databases

Overall and subgroup analysis If the OVERALL results show highly significant evidence of a worthwhile effect of treatment, but a few subgroups of the overview.

Meta-analysis: summarising data for two arm trials and other simple outcome studies Steff Lewis statistician.

Student Learning Development, TCD1 Systematic Approaches to Literature Reviewing Dr Tamara O’Connor Student Learning Development Trinity College Dublin.

The Bahrain Branch of the UK Cochrane Centre In Collaboration with Reyada Training & Management Consultancy, Dubai-UAE Cochrane Collaboration and Systematic.

Decision Analysis as a Basis for Estimating Cost- Effectiveness: The Experience of the National Institute for Health and Clinical Excellence in the UK.

Campbell Collaboration Colloquium 2012 Copenhagen, Denmark The effectiveness of volunteer tutoring programmes Dr Sarah Miller Centre.

Dr Amanda Perry Centre for Criminal Justice Economics and Psychology, University of York.

Making all research results publically available: the cry of systematic reviewers.

Are the results valid? Was the validity of the included studies appraised?

Department of O UTCOMES R ESEARCH. Daniel I. Sessler, M.D. Michael Cudahy Professor and Chair Department of O UTCOMES R ESEARCH The Cleveland Clinic Clinical.

1 Experimental Study Designs Dr. Birgit Greiner Dep. of Epidemiology and Public Health.

Systematic Reviews Professor Kate O’Donnell. Reviews Reviews (or overviews) are a drawing together of material to make a case. These may, or may not,

Data Analysis in Systematic Reviews-Meta Analysis.

SYSTEMATIC REVIEWS AND META-ANALYSIS. Objectives Define systematic review and meta- analysis Know how to access appraise interpret the results of a systematic.

1 ICEBOH Split-mouth studies and systematic reviews Ian Needleman 1 & Helen Worthington 2 1 Unit of Periodontology UCL Eastman Dental Institute International.

Simon Thornley Meta-analysis: pooling study results.

Systematic Reviews By Jonathan Tsun & Ilona Blee.

Kirsten Fiest, PhD June 23, CONDUCTING META-ANALYSES IN HEALTH RESEARCH.

Meta-analysis and “statistical aggregation” Dave Thompson Dept. of Biostatistics and Epidemiology College of Public Health, OUHSC Learning to Practice.

Levels of evidence and Interpretation of a systematic review

Objectives  Identify the key elements of a good randomised controlled study  To clarify the process of meta analysis and developing a systematic review.

Systematic Approaches to Literature Reviewing Dr Tamara O’Connor Student Learning Development

Doing a Systematic Review Jo Hunter Linda Atkinson Oxford University Health Care Libraries 1 March 2006 Workshops in Information Skills and Electronic.

Module 3 Finding the Evidence: Pre-appraised Literature.

1 Lecture 10: Meta-analysis of intervention studies Introduction to meta-analysis Selection of studies Abstraction of information Quality scores Methods.

Course: Research in Biomedicine and Health III Seminar 5: Critical assessment of evidence.

Systematic reviews and meta-analyses: when and how to do them Andrew Smith Royal Lancaster Infirmary 18 May 2015.

Evidence Based Practice (EBP) Riphah College of Rehabilitation Sciences(RCRS) Riphah International University Islamabad.

1 Lecture 10: Meta-analysis of intervention studies Introduction to meta-analysis Selection of studies Abstraction of information Quality scores Methods.

Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 27 Systematic Reviews of Research Evidence: Meta-Analysis, Metasynthesis,

Is a meta-analysis right for me? Jaime Peters June 2014.

Centre for Diet and Activity Research Social inequalities in physical activity: do environmental and policy interventions help reduce the gap? A pilot.

A Summary of a Systematic Review Robert Williams, LCSW, BCD University of Utah.

Linking analysis methods

Brady Et Al., "sequential compression device compliance in postoperative obstetrics and gynecology patients", obstetrics and gynecology, vol. 125, no.

Design of Experiments (DOE)

NURS3030H NURSING RESEARCH IN PRACTICE MODULE 7 ‘Systematic Reviews’’

Primer on Adjusted Indirect Comparison Meta-Analyses

Supplementary Table 1. PRISMA checklist

Randomized Trials: A Brief Overview

Evidence-Based Medicine

Effective evidence-based occupational therapy

Systematic reviews Dr Susan D Shenkin 1.

Heterogeneity and sources of bias

Lecture 4: Meta-analysis

STROBE Statement revision

H676 Meta-Analysis Brian Flay WEEK 1 Fall 2016 Thursdays 4-6:50

Association between risk-of-bias assessments and results of randomized trials in Cochrane reviews: the ROBES study Jelena Savović1, Becky Turner2, David.

Pilot Studies: What we need to know

Sue Todd Department of Mathematics and Statistics

Systematic reviews and meta-analysis

Gerald Dyer, Jr., MPH October 20, 2016

Dr. Maryam Tajvar Department of Health Management and Economics

Systematic review or meta-analysis

Systematic reviews and meta-analyses

EAST GRADE course 2019 Introduction to Meta-Analysis

David J.A. Jenkins et al. JACC 2018;71:

Fogarty International Training Program

What Really is Evidence Based Medicine?

Forest plot of randomised controlled trials investigating the effects of pasta in the context of low-GI dietary patterns on body weight (kg). n=2448. Forest.

Plot of the pooled effect estimates from randomised controlled trials investigating the effects of pasta in the context of low-GI dietary patterns on global.

Evidence-Based Public Health

David J.A. Jenkins et al. JACC 2018;71:

David J.A. Jenkins et al. JACC 2018;71:

Presentation transcript:

Dr. Maryam Tajvar Department of Health Management and Economics META ANALYSIS Dr. Maryam Tajvar Department of Health Management and Economics

How do a systematic review?

Data synthesis Descriptively Mathematically (Meta-analysis)

What is a meta-analysis? "the statistical analysis of the data from a collection of studies in order to synthesise the results". The quantitative synthesis of findings from separate, but related studies ... usually RCTs. Cook, D. J., D. L. Sackett, et al. (1995). “Methodologic guidelines for systematic reviews of randomized control trials in health care from the Potsdam Consultation on Meta-Analysis.” J Clin Epidemiol 48(1): 167-71.

Purposes of meta-analysis Obtain overall summary estimate to improve precision Test whether an “intervention” is effective with increase power Assess whether results of different studies are heterogeneous Greater objectivity, precision and applicability by including all available evidence.

Principles of meta-analysis Produce a “forest plot” Investigate heterogeneity between studies Pool results

“forest plot”

Investigating heterogeneity: Chi-squared test of heterogeneity: when statistically significant heterogeneity, may not be appropriate to pool data and do meta analysis - So when we see heterogeneity, Don’t meta-analyse!!! You may explore the causes of the heterogeneity through sub-group analysis

Calculating summary statistics Systematic review software , e.g. Review Manager (RevMan) , will calculate pooled results for you. STATA has very good MA commands, but some of them have to be installed separately

Guidelines on how to write reviews & meta-analyses: –QUORUM statement* For meta-analysis of RCTs –MOOSE guidelines** For meta-analysis of observational studies *Moher et al. The Lancet 1999;354:1896-1900. **Stroup et al. JAMA 2000;283:2008-2012.

Useful links Cochrane Collaboration -www.cochrane.org The York Centre for Reviews and Dissemination -www.york.ac.uk/inst/crd/index.htm School of Health and Related Research, Sheffield -http://www.shef.ac.uk/scharr/sections/ir/links Especially for non-RCTs –Campbell Collaboration - http://www.campbellcollaboration.org/