Association Between Nonalcoholic Hepatic Steatosis and Hepatic Cytochrome P-450 3A Activity  Dhanashri Kolwankar, Raj Vuppalanchi, Brian Ethell, David R. Jones, Steven A. Wrighton, Stephen D. Hall, Naga Chalasani  Clinical Gastroenterology and Hepatology  Volume 5, Issue 3, Pages 388-393 (March 2007) DOI: 10.1016/j.cgh.2006.12.021 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 (A) Relationship between CYP3A5 genotype and expression of wt and SV1 mRNA in subjects who express at least one CYP3A5*1 allele (n = 12; one subject with genotype CYP3A5*1/*1, *1/*6, *1/*7 was not included because of inability to precisely characterize the genotype) and CYPA5*3/*3 (n = 34; no RNA could be isolated from 2 samples). Relative mRNA values are in attograms/attograms after normalization to 18S RNA used as a housekeeping gene. (B) Relationship between CYP3A5 genotype in subjects who express at least one CYP3A5*1 allele (n = 12; one subject with genotype CYP3A5*1/*1, *1/*6, *1/*7 was excluded from analysis because of inability to precisely characterize the genotype) and CYPA5*3/ *3 (n= 34; no RNA could be isolated from 2 samples) with their CYP3A4 mRNA expression and CYP3A activity. Data are shown as mean ± standard error. Clinical Gastroenterology and Hepatology 2007 5, 388-393DOI: (10.1016/j.cgh.2006.12.021) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 Relationship between hepatic CYP3A activity and severity of steatosis. Steatosis was categorized into none (n = 25), mild (≥5%–33% steatosis) (n = 20) or moderate steatosis (>33%) (n = 4). Data are shown as mean ± standard error. Clinical Gastroenterology and Hepatology 2007 5, 388-393DOI: (10.1016/j.cgh.2006.12.021) Copyright © 2007 AGA Institute Terms and Conditions