Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization Hani A. Hennein,

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Presentation transcript:

Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization Hani A. Hennein, MDa, Hailu Ebba, MDa, Jorge L. Rodriguez, MDb, Scot H. Merrick, MDa, Fraser M. Keith, MDa, Merrill H. Bronstein, MDa, Jacqueline M. Leung, MDa, Dennis T. Mangano, MD, PhDa, Lazar J. Greenfield, MDb, J.Scott Rankin, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 108, Issue 4, Pages 626-635 (October 1994) DOI: 10.5555/uri:pii:S0022522394702861 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 TNF-α levels after uncomplicated coronary artery bypass grafting. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 626-635DOI: (10.5555/uri:pii:S0022522394702861) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 IL-6 levels after uncomplicated coronary artery bypass grafting. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 626-635DOI: (10.5555/uri:pii:S0022522394702861) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 IL-8 levels after uncomplicated coronary artery bypass grafting. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 626-635DOI: (10.5555/uri:pii:S0022522394702861) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 TNF-α levels measured from various vascular beds before and directly after termination of CPB. In all instances, post-CPB levels were significantly elevated compared to their pre-CPB levels (p < 0.01). PV, Pulmonary vein; SA, systemic artery; PA, pulmonary artery; CS, coronary sinus. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 626-635DOI: (10.5555/uri:pii:S0022522394702861) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 5 Systemic arterial and pulmonary arterial TNF-α levels in a single patient after CPB. Systemic arterial cytokine levels peaked earlier, and often rose higher, than simultaneously drawn pulmonary arterial levels. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 626-635DOI: (10.5555/uri:pii:S0022522394702861) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 6 Relationship between the aortic crossclamp time and early IL-6 levels after CPB. Solid line: regression (expected values) line; dotted line: 95% confidence interval. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 626-635DOI: (10.5555/uri:pii:S0022522394702861) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 7 Relationship between early post-CPB IL-6 levels and the change intransesophageal echocardiography WMS after coronary revascularization. More negative transesophageal echocardiography WMS signify improvement in score. Solid line: regression (expected values) line; dotted line: 95% confidence interval. Echo, Echocardiography. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 626-635DOI: (10.5555/uri:pii:S0022522394702861) Copyright © 1994 Mosby, Inc. Terms and Conditions