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Volume 4, Issue 5, Pages 429-433 (June 2018) Concurrence of psoriasis vulgaris and atopic eczema in a single patient exhibiting different expression patterns of psoriatic autoantigens in the lesional skin Sachiko Ono, MD, PhD, Tetsuya Honda, MD, PhD, Hiromi Doi, MA, Kenji Kabashima, MD, PhD JAAD Case Reports Volume 4, Issue 5, Pages 429-433 (June 2018) DOI: 10.1016/j.jdcr.2017.11.026 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Concurrence of AD and Pso lesions in a single patient. A, Concurrence of a Pso lesion (black square) and an AD lesion (yellow square) on the trunk. B, Hematoxylin-eosin stain of each skin lesion. Bar = 200 μm. C, mRNA expression levels of cytokines in each skin lesion and in normal skin taken from 3 healthy controls, examined by qPCR. JAAD Case Reports 2018 4, 429-433DOI: (10.1016/j.jdcr.2017.11.026) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Expression levels of cytokines in the patient compared with those of naïve AD and PSO. qPCR analysis of mRNA expression levels of IL13, IL17A, IL17F, IL22, and IL23A in different skin lesions. Samples were taken from the Pso lesion and AD lesion of the patient, the Pso lesion of naive Pso patients (n = 4), the AD lesion of naive AD patients (n = 5), and normal skin of healthy controls (n = 3). Expression levels of IL4, IL5, and IFNγ were under detection limit in most samples in this trial. JAAD Case Reports 2018 4, 429-433DOI: (10.1016/j.jdcr.2017.11.026) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Expression of psoriatic autoantigens in the lesional skin. Immunohistochemical staining of ADAMTSL5 (red) (A) or LL-37 (brown) (B, left) in the Pso and AD lesions. Blue in (A) indicates nuclei stained with DAPI. Arrows indicate positive-staining cells. Lower panels indicate the high magnification of squares in the upper panels. mRNA expression levels of CAMP in each skin lesion compared with samples of healthy controls (B, right). ND, Not detected. JAAD Case Reports 2018 4, 429-433DOI: (10.1016/j.jdcr.2017.11.026) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions