Managing Rare CKDs.

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Presentation transcript:

Managing Rare CKDs

Gaps in Role of Inflammation in Rare CKDs

IgA Nephropathy

Focal Segmental Glomerulosclerosis

Evolution of Understanding the Progressive Nature of Kidney Disease

Anti-Inflammatory Drugs in Nephrology?

Personalized Medicine Genes Involved in FSGS

Treatment Options for Patients With CKD

Bardoxolone Mechanism of Action

PHOENIX Study Bardoxolone in Patients With Rare CKDs

CARDINAL Study Bardoxolone in Patients With Alport Syndrome

Bardoxolone Phase 2 Results Improvement in eGFR

TSUBAKI Study (Japan) in Patients With Diabetic CKD

BEAM Study Increasing Proteinuria With Increasing eGFR at 52 Weeks

Increases in Urinary Protein Are Consistent With Increases in GFR and Not Injury

Sustained Increase in eGFR Following Withdrawal of Bardoxolone Insights From BEACON Study

Bardoxolone Change in Disease Pathophysiology?

Take-Home Messages

Abbreviations

Abbreviations (cont)

Abbreviations (cont)

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