Challenges in Severe Asthma

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Presentation transcript:

Challenges in Severe Asthma

Severe Asthma Has a Huge Burden

Asthma Is a Heterogeneous Disease

Defining Severe and Uncontrolled Asthma

Case Leon

History and Work-Up

Comorbidities

History and Work-Up (cont)

Asthma Phenotypes and Endotypes

Pathophysiology T2 Asthma and Eosinophils

Pathophysiology T2 Asthma and ILC2 Cells

Pathophysiology Non-T2 Asthma

Leon Treatment Options

Biomarkers

Biomarkers Results

IL-5 Targeted Agents for Eosinophilic Asthma

Other Targeted Agents

Options for Non-T2 Asthma

Concluding Remarks

Abbreviations

Abbreviations (cont)

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