Measurement accuracy of focal cartilage defects from MRI and correlation of MRI graded lesions with histology: a preliminary study Chris A McGibbon,

Slides:

Advertisements

Similar presentations

Author :J. Carballido-Gamio J.S. Bauer Keh-YangLeeJ. Carballido-GamioJ.S. BauerKeh-YangLee S. Krause S. MajumdarS. KrauseS. Majumdar Source : 27th Annual.

Advertisements

Date of download: 6/21/2016 Copyright © ASME. All rights reserved. From: In Vitro Quantification of Time Dependent Thrombus Size Using Magnetic Resonance.

Date of download: 9/25/2017 Copyright © ASME. All rights reserved.

Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer C.B. Raub, S.C. Hsu, E.F. Chan, R. Shirazi,

A. Williams, Y. Qian, S. Golla, C.R. Chu Osteoarthritis and Cartilage

Automated segmentation and analysis of normal and osteoarthritic knee menisci from magnetic resonance images – data from the Osteoarthritis Initiative

Knee osteoarthritis patients with severe nocturnal pain have altered proximal tibial subchondral bone mineral density W.D. Burnett, S.A. Kontulainen,

2D and 3D MOCART scoring systems assessed by 9

Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage R.E. Wilusz, S. Zauscher, F. Guilak

Considerations in measuring cartilage thickness using MRI: factors influencing reproducibility and accuracy S. Koo, M.S., G.E. Gold, M.D., T.P. Andriacchi,

Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits E. Calvo, M.D., S. Castañeda, M.D., R.

Anisotropy of collagen fibre alignment in bovine cartilage: comparison of polarised light microscopy and spatially resolved diffusion-tensor measurements

Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer C.B. Raub, S.C. Hsu, E.F. Chan, R. Shirazi,

Two year longitudinal change and test–retest-precision of knee cartilage morphology in a pilot study for the osteoarthritis initiative F. Eckstein, M.D.,

A. Williams, Y. Qian, D. Bear, C.R. Chu Osteoarthritis and Cartilage

Hisham A. Alhadlaq, M.S., Yang Xia, Ph.D. Osteoarthritis and Cartilage

An MRI derived articular cartilage visualization framework

Treatment of full thickness focal cartilage lesions with a metallic resurfacing implant in a sheep animal model, 1 year evaluation N. Martinez-Carranza,

MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers Garry E. Gold, Deborah Burstein, Bernard Dardzinski, Phillip.

Experimental scoring systems for macroscopic articular cartilage repair correlate with the MOCART score assessed by a high-field MRI at 9.4 T – comparative.

Determining collagen distribution in articular cartilage using contrast-enhanced micro- computed tomography H.J. Nieminen, T. Ylitalo, S. Karhula, J.-P.

In situ deformation of cartilage in cyclically loaded tibiofemoral joints by displacement- encoded MRI D.D. Chan, C.P. Neu, M.L. Hull Osteoarthritis.

Computer-aided quantification of focal cartilage lesions using MRI: Accuracy and initial arthroscopic comparison Keh-Yang Lee, Ph.D., Jeffrey N. Masi,

Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems –

Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight I.G. Otterness, Ph.D., F. Eckstein, M.D.

Differences between X-ray and MRI-determined knee cartilage thickness in weight- bearing and non-weight-bearing conditions M. Marsh, R.B. Souza, B.T.

Cluster analysis of quantitative MRI T2 and T1ρ relaxation times of cartilage identifies differences between healthy and ACL-injured individuals at 3T

Regional variations of collagen orientation in normal and diseased articular cartilage and subchondral bone determined using small angle X-ray scattering.

Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees G.J. Kazakia, D. Kuo, J. Schooler, S.

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the guinea pig V.B. Kraus, J.L. Huebner, J. DeGroot,

B. Bittersohl, F. R. Miese, H. S. Hosalkar, M. Herten, G. Antoch, R

The innervation of synovium of human osteoarthritic joints in comparison with normal rat and sheep synovium A. Eitner, J. Pester, S. Nietzsche, G.O.

Change in bone area does not correlate with cartilage loss over 12 months in individuals with knee OA: Data from the osteoarthritis initiative M.A. Bowes,

A polarized light microscopy method for accurate and reliable grading of collagen organization in cartilage repair A. Changoor, N. Tran-Khanh, S. Méthot,

B.D. Bomsta, M.S., L.C. Bridgewater, Ph.D., R.E. Seegmiller, Ph.D.

Nondestructive assessment of sGAG content and distribution in normal and degraded rat articular cartilage via EPIC-μCT L. Xie, A.S.P. Lin, R.E. Guldberg,

L. Bian, S. L. Angione, K. W. Ng, E. G. Lima, D. Y. Williams, D. Q

A.C. Dang, M.D., A.P. Warren, M.D., H.T. Kim, M.D., Ph.D.

Automatic morphometric cartilage quantification in the medial tibial plateau from MRI for osteoarthritis grading E.B. Dam, Ph.D., J. Folkesson, M.Sc.,

Lateral trunk lean explains variation in dynamic knee joint load in patients with medial compartment knee osteoarthritis M.A. Hunt, P.T., Ph.D., T.B.

Observations of subchondral plate advancement during osteochondral repair: a histomorphometric and mechanical study in the rabbit femoral condyle Y.-S.

Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging S.K. de Visser, B.Eng. (Med.), R.W. Crawford, D.Phil.,

R. Lattanzi, C. Petchprapa, D. Ascani, J. S. Babb, D. Chu, R. I

Quantitative MR T2 measurement of articular cartilage to assess the treatment effect of intra-articular hyaluronic acid injection on experimental osteoarthritis.

K. D. Novakofski, R. M. Williams, L. A. Fortier, H. O. Mohammed, W. R

Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA study D.

Opposing cartilages in the patellofemoral joint adapt differently to long-term cruciate deficiency: chondrocyte deformation and reorientation with compression

A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open- source tool for histological grading H.E. Kloefkorn, B.Y. Jacobs,

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage F. Wei, J. Zhou, X. Wei,

How do short-term rates of femorotibial cartilage change compare to long-term changes? Four year follow-up data from the osteoarthritis initiative F.

Focal knee resurfacing and effects of surgical precision on opposing cartilage. A pilot study on 12 sheep N. Martinez-Carranza, H.E. Berg, K. Hultenby,

K. E. Keenan, T. F. Besier, J. M. Pauly, E. Han, J. Rosenberg, R. L

Comparison of BLOKS and WORMS scoring systems part I

A novel method for assessing signal intensity within infrapatellar fat pad on MR images in patients with knee osteoarthritis M. Lu, Z. Chen, W. Han,

Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis E. Calvo, M.D., I. Palacios,

Templates of the cartilage layers of the patellofemoral joint and their use in the assessment of osteoarthritic cartilage damage Z.A Cohen, Ph.D., V.C.

X. Li, Ph. D. , C. Benjamin Ma, M. D. , T. M. Link, M. D. , D. -D

Bone marrow lesions identified by MRI in knee osteoarthritis are associated with locally increased bone mineral density measured by QCT T. Lowitz, O.

Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change? D.J. Hunter, L. Li, Y.Q. Zhang, S. Totterman,

Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repair A.C. Kuo, M.D., Ph.D., J.J. Rodrigo, M.D.,

Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage I. Holloway, M. Kayser, D.A. Lee, D.L. Bader,

Computed tomography topographic mapping of subchondral density (CT-TOMASD) in osteoarthritic and normal knees: methodological development and preliminary.

The canine ‘groove’ model of osteoarthritis is more than simply the expression of surgically applied damage Simon C. Mastbergen, M.Sc., Anne C. Marijnissen,

3D modelling of the hip joint from clinical imaging data

I. G. Otterness, Ph. D. , M. -P. H. Le Graverand, M. D. , Ph. D. , F

Correlation between the MR T2 value at 4

Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen.

Preliminary study on diffraction enhanced radiographic imaging for a canine model of cartilage damage C. Muehleman, Ph.D., J. Li, M.D., Z. Zhong, Ph.D.

B.D. Bomsta, M.S., L.C. Bridgewater, Ph.D., R.E. Seegmiller, Ph.D.

Three-dimensional distribution of acetabular cartilage thickness in patients with hip dysplasia: a fully automated computational analysis of MR imaging

Presentation transcript:

Measurement accuracy of focal cartilage defects from MRI and correlation of MRI graded lesions with histology: a preliminary study Chris A McGibbon, Ph.D., Carol A Trahan, B.A. Osteoarthritis and Cartilage Volume 11, Issue 7, Pages 483-493 (July 2003) DOI: 10.1016/S1063-4584(03)00078-5

Fig. 1 Features of the 3D reconstruction model, as applied to a knee joint with severe OA degeneration. (a) The knee joint shown as a light shaded surface rendering. (b) The same knee joint shown as a cartilage thickness distribution map. (c) A zoomed in region of the surface detailing surface contours which can be measured by the user. The edge dimension refers to the vertical (longitudinal) dimension along the surface of the joint as defined by the MR image plane, and the slice dimension refers to the horizontal (transverse) dimension across the slices. Osteoarthritis and Cartilage 2003 11, 483-493DOI: (10.1016/S1063-4584(03)00078-5)

Fig. 2 Defect size measurement for an artificially created defect from one of the knee specimens. The defect created was 2.50mm in diameter and 1.50mm in depth. Top left: An MR image showing the defect. Top right: The defect dimensions as measured from the in-plane image (shown segmented for clarity). This defect measured 2.50mm in diameter and 1.56mm in depth. Bottom: A zoomed map of the artificially created surface defect showing spatial thickness contours. A measurement tool is used to measure the dimensions (diameter and depth) across the defect, horizontally and vertically, which can then be averaged to present the defect dimensions. The defect as measured by the computer tool was 2.15mm in diameter and 1.06mm in depth. The edge dimension refers to the vertical (longitudinal) dimension along the surface of the joint as defined by the MR image plane, and the slice dimension refers to the horizontal (transverse) dimension across the slices. Osteoarthritis and Cartilage 2003 11, 483-493DOI: (10.1016/S1063-4584(03)00078-5)

Fig. 3 Scatter plot and regression line of the relationship between Noyes grading scale and Mankin grading scale of 20 selected sites on three knees. The correlation coefficient of the two independent measures was r=0.7. Osteoarthritis and Cartilage 2003 11, 483-493DOI: (10.1016/S1063-4584(03)00078-5)

Fig. 4 An example of MR appearance of two selected sites on a single image from the left knee of a 100-year-old female, with corresponding histological stained micrographs of the two sites. The inset table shows the Noyes (N) and Mankin (M) grades of the sites. Numbers in parentheses are the scores normalized to a 0–100 scale for comparison purposes. Osteoarthritis and Cartilage 2003 11, 483-493DOI: (10.1016/S1063-4584(03)00078-5)

Fig. 5 An example of MR appearance of two selected sites on a single image from the right knee of a 100-year-old female, with corresponding histological stained micrographs of the two sites. The inset table shows the Noyes (N) and Mankin (M) grades of the sites. Numbers in parentheses are the scores normalized to a 0–100 scale for comparison purposes. Osteoarthritis and Cartilage 2003 11, 483-493DOI: (10.1016/S1063-4584(03)00078-5)