Evaluation of a Scoring System for Assessing Prognosis in Pediatric Acute Liver Failure  Brandy R. Lu, Jane Gralla, Edwin Liu, Emily L. Dobyns, Michael R. Narkewicz, Ronald J. Sokol  Clinical Gastroenterology and Hepatology  Volume 6, Issue 10, Pages 1140-1145 (October 2008) DOI: 10.1016/j.cgh.2008.05.013 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Validation of the LIU score using the INR. (A) Survival without LT stratified by quartiles developed on the previously defined training set. LIU = 3.507×peak total bilirubin (mg/dL) + 45.51×peak INR + 0.254×peak ammonia (umol/L). A low risk of death or LT (LIU score < 209) and a high risk of death or LT (LIU score ≥370) can be defined. (B) ROC curves for predicting death or LT at 4 weeks using the LIU score. A C index of greater than 85 is considered predictive. The C index was 86.3 (95% CI, 75.6–97.4). Clinical Gastroenterology and Hepatology 2008 6, 1140-1145DOI: (10.1016/j.cgh.2008.05.013) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Validation of the LIU score using PT. (A) Survival without LT stratified by quartiles developed on the previously defined training set. LIU = 3.584×peak total bilirubin (mg/dL) + 1.809×peak PT (s) + 0.307×peak ammonia (umol/L). A low risk of death or LT (LIU score < 152) and a high risk of death or LT (LIU score ≥228) can be defined. (B) ROC curve for predicting death or LT at 4 weeks using the LIU score. The C index was 80.6 (95% CI, 65.7–95.3). Clinical Gastroenterology and Hepatology 2008 6, 1140-1145DOI: (10.1016/j.cgh.2008.05.013) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Derivation of the aLIU score using the INR. (A) Survival without LT stratified by quartiles developed using the newly derived aLIU score. aLIU = 8.4 × admission bilirubin (mg/dL) + 50.0 × admission INR. A low risk of death or LT (aLIU < 310) and a high risk of death or LT (aLIU ≥ 310) can be defined based on admission values. (B) ROC curve for predicting death or LT at 4 weeks using the aLIU score. The C index was 83.7 (95% CI, 71.8–95.9). Clinical Gastroenterology and Hepatology 2008 6, 1140-1145DOI: (10.1016/j.cgh.2008.05.013) Copyright © 2008 AGA Institute Terms and Conditions

Figure 4 Derivation of the aLIU score using PT. (A) Survival without LT stratified by quartiles developed using the newly derived aLIU score. aLIU = 6.9 × admission bilirubin (mg/dL) + 4.0 × admission PT. A low risk of death or LT (aLIU < 233) and a high risk of death or LT (aLIU ≥ 233) can be defined based on admission values. (B) ROC curve for predicting death or LT at 4 weeks using the aLIU score. The C index was 78.9 (95% CI, 64.3–93.6). Clinical Gastroenterology and Hepatology 2008 6, 1140-1145DOI: (10.1016/j.cgh.2008.05.013) Copyright © 2008 AGA Institute Terms and Conditions