M. C. Gallo, C. Wyatt, V. Pedoia, D. Kumar, S. Lee, L. Nardo, T. M

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T1ρ and T2 relaxation times are associated with progression of hip osteoarthritis M.C. Gallo, C. Wyatt, V. Pedoia, D. Kumar, S. Lee, L. Nardo, T.M. Link, R.B. Souza, S. Majumdar Osteoarthritis and Cartilage Volume 24, Issue 8, Pages 1399-1407 (August 2016) DOI: 10.1016/j.joca.2016.03.005 Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Division and numbering of the eight subregions of hip cartilage on the MERGE image. The solid yellow line represents a reference line parallel with the femoral neck that is drawn for each subject. Osteoarthritis and Cartilage 2016 24, 1399-1407DOI: (10.1016/j.joca.2016.03.005) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 T1ρ relaxation map overlay of baseline (Left) and 18-month follow-up (Right) for a femoral cartilage lesion progressor with baseline KL = 0 (Female, Age 65). Note the marked increase in relaxation time in the posterosuperior femoral cartilage (arrow), which corresponds to subregion 3. Osteoarthritis and Cartilage 2016 24, 1399-1407DOI: (10.1016/j.joca.2016.03.005) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Sagittal intermediate-weighted MR images demonstrate progression of cartilage loss: at baseline (a) anterior femoral cartilage partial-thickness lesion (arrows) and at 18-month follow-up (b) full-thickness cartilage lesion at the same site (long arrowheads). Opposing anterior acetabular cartilage that was intact on baseline shows new partial thickness cartilage lesion (short arrowheads) at follow up. Osteoarthritis and Cartilage 2016 24, 1399-1407DOI: (10.1016/j.joca.2016.03.005) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Average T1ρ and T2 relaxation time maps for progressors (a,b) and non-progressors (c,d) in the atlas coordinate system. (e,f) P value SPM comparing local differences between progressors and non-progressors. Osteoarthritis and Cartilage 2016 24, 1399-1407DOI: (10.1016/j.joca.2016.03.005) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions