Targeting the Undruggable Proteome: The Small Molecules of My Dreams

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Presentation transcript:

Targeting the Undruggable Proteome: The Small Molecules of My Dreams Craig M. Crews Chemistry & Biology Volume 17, Issue 6, Pages 551-555 (June 2010) DOI: 10.1016/j.chembiol.2010.05.011 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Strategies for Using Cellular Protein Degradation Machinery to Control Intracellular Protein Levels (A) Schematic of inducing protein degradation via recruitment to the proteasome or lysosome. (B) Design of a PROTAC-based library targeting protein function independently of protein class. Chemistry & Biology 2010 17, 551-555DOI: (10.1016/j.chembiol.2010.05.011) Copyright © 2010 Elsevier Ltd Terms and Conditions