Differences in the robustness of clusters involving the Mycobacterium tuberculosis strains most frequently isolated from immigrant cases in Madrid N.

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Presentation transcript:

Differences in the robustness of clusters involving the Mycobacterium tuberculosis strains most frequently isolated from immigrant cases in Madrid N. Alonso Rodríguez, M. Martínez Lirola, F. Chaves, J. lñigo, M. Herranz, V. Ritacco, E. Bouza, D. García de Viedma Clinical Microbiology and Infection Volume 16, Issue 10, Pages 1544-1554 (October 2010) DOI: 10.1111/j.1469-0691.2010.03161.x Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Representative features from the large clusters involving immigrants in Madrid. RFLP, restriction fragment length polymorphism. Clinical Microbiology and Infection 2010 16, 1544-1554DOI: (10.1111/j.1469-0691.2010.03161.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Distribution of the large clusters involving immigrants in categories of expected epidemiological value (high, intermediate and low). The number of matches identified in Almeria, and the mycobacterial interspersed repetitive units (MIRU) type for the representatives of each of the large clusters, are shown. RFLP, restriction fragment length polymorphism. MIRU-15 loci showing differences are highlighted in colour. Clinical Microbiology and Infection 2010 16, 1544-1554DOI: (10.1111/j.1469-0691.2010.03161.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Analysis of isolates sharing the M6 restriction fragment length polymorphism type in the Madrid (a), Almería (b), and Latin American (c) samples. The figure shows the mycobacterial interspersed repetitive units (MIRU) type, SpolDB4 family and country of origin of the corresponding cases. MIRU type clusters are indicated in grey. Alleles showing single locus variations with the other representatives in the MIRU cluster are shown in light grey. Orphan MIRU types are shown in white. Clinical Microbiology and Infection 2010 16, 1544-1554DOI: (10.1111/j.1469-0691.2010.03161.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Geographic distribution of the cases infected by M6 isolates in Almería. The subclusters identified by mycobacterial interspersed repetitive units (MIRU) within the restriction fragment length polymorphism-defined M6 cluster are shown as numbers. White squares represent the cases clustered by MIRU. Black squares represent cases shown as orphan (o) by MIRU. Clinical Microbiology and Infection 2010 16, 1544-1554DOI: (10.1111/j.1469-0691.2010.03161.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions