Variable CDR3 lengths support the notion of oligoclonality in CD8+ T cells of lupus-prone mice. Variable CDR3 lengths support the notion of oligoclonality.

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Variable CDR3 lengths support the notion of oligoclonality in CD8+ T cells of lupus-prone mice. Variable CDR3 lengths support the notion of oligoclonality in CD8+ T cells of lupus-prone mice. (A) Relative abundance and distribution of CDR3 nucleotide sequence lengths (bp) from purified CD8+ T cells of wild type B6 spleen (shades of gray), TLR7tg spleen (shades of red), and TLR7tg brain (shades of blue). Each shaded bar represents a separate sample of the indicated genotype and tissue. For each possible CDR3 length, the order of the eight bars from left to right is matched for spleen and brain samples from TLR7tg mice. (B) Average distribution analysis of compiled samples (n = 8) from (A). Bars indicate minimum and maximum values centered on the mean. R2 values indicate the fit of each curve to normal Gaussian distribution. Peter A. Morawski, and Silvia Bolland ImmunoHorizons 2019;3:61-70 ©2019 by American Association of Immunologists