Bo Shopsin, Srini V. Kaveri, Jagadeesh Bayry Cell Host & Microbe

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Presentation transcript:

Tackling Difficult Staphylococcus aureus Infections: Antibodies Show the Way Bo Shopsin, Srini V. Kaveri, Jagadeesh Bayry Cell Host & Microbe Volume 20, Issue 5, Pages 555-557 (November 2016) DOI: 10.1016/j.chom.2016.10.018 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Tackling Difficult Staphylococcus aureus Infections by Antibody-Based Therapies (A) Elimination of the intracellular pool of S. aureus during bacteremia using an antibody-antibiotic conjugate (AAC). The S. aureus wall teichoic acid (WTA)-specific IgG of AAC opsonize free bacteria and are taken up by phagocytic cells via Fcγ-receptors. Inside the phagolysosome, antibiotic (rifalogue) is released from AAC through cleavage of the linker by cathepsins. Rifalogue then kills the bacteria. (B) IVIG therapy protects rabbits from necrotizing pneumonia caused by MRSA. The protection by IVIG is mediated mainly via IgG to critical toxins Panton-Valentine leukocidin (PVL) and α-hemolysin (Hla) that contribute to the pathogenesis of necrotizing pneumonia. Cell Host & Microbe 2016 20, 555-557DOI: (10.1016/j.chom.2016.10.018) Copyright © 2016 Elsevier Inc. Terms and Conditions