Dystroglycan Versatility

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Dystroglycan Versatility Martin E. Hemler Cell Volume 97, Issue 5, Pages 543-546 (May 1999) DOI: 10.1016/S0092-8674(00)80764-3

Figure 1 Dystroglycan in Skeletal Muscle (A) Dystroglycan (DG) spans the sarcolemma, linking extracellular laminin-2 with the cytoskeleton. (B) Dystroglycan in synaptic basal lamina of neuromuscular junctions binds to extracellular laminin-2 and agrin, and intracellular utrophin. Association with the rapsyn protein may provide a link to the acetylcholine receptor (AChR). Relevant O-linked glycosylation sites are indicated on α-dystroglycan. Cell 1999 97, 543-546DOI: (10.1016/S0092-8674(00)80764-3)

Figure 2 Dystroglycan in Nonmuscle Cells (A) Dystroglycan in epithelial cells binds to laminin-1, and perlecan and supports basement membrane assembly. An isoform of agrin also binds tightly to dystroglycan in lung, kidney, and brain. (B) On a variety of cell types, dystroglycan binds to arenaviruses. (C) Dystroglycan binds, via laminin-2, to M. leprae–laminin-2 complexes. Cell 1999 97, 543-546DOI: (10.1016/S0092-8674(00)80764-3)