Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial Dr Pallavi Mandal, MRCP, James D Chalmers, MRCP, Catriona Graham,

Slides:

Advertisements

Similar presentations

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials The Lancet Volume 386, Issue.

Advertisements

Seasonal dynamics of bacterial meningitis: a time-series analysis Dr Juliette Paireau, PhD, Angelica Chen, Helene Broutin, PhD, Prof Bryan Grenfell, PhD,

Volume 386, Issue 9988, Pages (July 2015)

Volume 357, Issue 9257, Pages (March 2001)

Volume 1, Issue 7, Pages (December 2014)

Individual gene expression and personalised medicine in sepsis

Effect of a bereavement support group on female adolescents' psychological health: a randomised controlled trial in South Africa Prof Tonya Renee Thurman,

Volume 386, Issue 9992, Pages (August 2015)

Volume 388, Issue 10042, Pages (July 2016)

Estimated need for surgery worldwide based on prevalence of diseases: a modelling strategy for the WHO Global Health Estimate John Rose, MD, Thomas G.

Volume 14, Issue 1, Pages (January 2015)

Socioeconomic inequality in neonatal mortality in countries of low and middle income: a multicountry analysis Britt McKinnon, MSc, Sam Harper, PhD, Prof.

Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial Chinedu.

Self-assessment of the outcome of early medical abortion versus clinic follow-up in India: a randomised, controlled, non-inferiority trial Dr Kirti Iyengar,

Effect of a lifestyle intervention on weight change in south Asian individuals in the UK at high risk of type 2 diabetes: a family-cluster randomised.

Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial

Volume 152, Issue 2, Pages (August 2017)

Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation.

Volume 15, Issue 10, Pages (September 2014)

Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled.

Volume 388, Issue 10052, Pages (October 2016)

Volume 383, Issue 9925, Pages (April 2014)

Volume 14, Issue 4, Pages (April 2015)

Effects of community health interventions on under-5 mortality in rural Guinea-Bissau (EPICS): a cluster-randomised controlled trial Dr Peter Boone,

Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study Dr James D Chalmers, MBChB, Brian J.

Effects of a parenting intervention to address maternal psychological wellbeing and child development and growth in rural Uganda: a community-based, cluster-randomised.

Volume 3, Issue 2, Pages (February 2016)

Self-assessment of the outcome of early medical abortion versus clinic follow-up in India: a randomised, controlled, non-inferiority trial Dr Kirti Iyengar,

Montelukast for postinfectious cough in adults: a double-blind randomised placebo- controlled trial Dr Kay Wang, DPhil, Surinder S Birring, MD, Kathryn.

Estimated need for surgery worldwide based on prevalence of diseases: a modelling strategy for the WHO Global Health Estimate John Rose, MD, Thomas G.

Effect of nicotine patches in pregnancy on infant and maternal outcomes at 2 years: follow-up from the randomised, double-blind, placebo-controlled SNAP.

Tackling stigma: fundamental to an AIDS-free future

Volume 386, Issue 9998, Pages (September 2015)

Volume 375, Issue 9732, Pages (June 2010)

Lung cancer diagnosis and staging with endobronchial ultrasound-guided transbronchial needle aspiration compared with conventional approaches: an open-label,

Effect of a community-led sanitation intervention on child diarrhoea and child growth in rural Mali: a cluster-randomised controlled trial Dr Amy J Pickering,

Effect of a knowledge-based and skills-based programme for physicians on risk of sexually transmitted reinfections among high-risk patients in China:

Effect of antenatal multiple micronutrient supplementation on anthropometry and blood pressure in mid-childhood in Nepal: follow-up of a double-blind.

The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis Prof Karen Hughes, PhD, Prof Mark A Bellis, DSc,

Health consequences of exposure to e-waste: a systematic review

Socioeconomic inequality in neonatal mortality in countries of low and middle income: a multicountry analysis Britt McKinnon, MSc, Sam Harper, PhD, Prof.

Volume 383, Issue 9918, Pages (February 2014)

Volume 14, Issue 9, Pages (September 2015)

Volume 386, Issue 9992, Pages (August 2015)

Volume 382, Issue 9890, Pages (August 2013)

Volume 15, Issue 12, Pages (November 2014)

Cardiovascular and neuropsychiatric risks of varenicline: a retrospective cohort study Prof Daniel Kotz, PhD, Wolfgang Viechtbauer, PhD, Colin Simpson,

Effect of a bereavement support group on female adolescents' psychological health: a randomised controlled trial in South Africa Prof Tonya Renee Thurman,

Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial

Volume 388, Issue 10042, Pages (July 2016)

Volume 3, Issue 6, Pages (June 2016)

Volume 386, Issue 9998, Pages (September 2015)

Neuromuscular electrical stimulation to improve exercise capacity in patients with severe COPD: a randomised double-blind, placebo-controlled trial Dr.

Volume 16, Issue 8, Pages (August 2015)

Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial Prof Lucilla Poston, PhD,

Internet-based intervention for smoking cessation (StopAdvisor) in people with low and high socioeconomic status: a randomised controlled trial Dr Jamie.

Volume 384, Issue 9957, Pages (November 2014)

Volume 386, Issue 10005, Pages (October 2015)

Life expectancy among HIV-positive patients in Rwanda: a retrospective observational cohort study Sabin Nsanzimana, MD, Eric Remera, MSc, Steve Kanters,

Rapid diagnosis of pulmonary tuberculosis in African children in a primary care setting by use of Xpert MTB/RIF on respiratory specimens: a prospective.

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial Dr David Preiss, PhD, Suzanne M Lloyd,

Kathleen M Neuzil, Karen L Kotloff The Lancet Global Health

Volume 383, Issue 9926, Pages (April 2014)

Volume 14, Issue 9, Pages (September 2015)

Volume 2, Issue 4, Pages (April 2015)

Volume 387, Issue 10029, Pages (April 2016)

Oxytocin via Uniject (a prefilled single-use injection) versus oral misoprostol for prevention of postpartum haemorrhage at the community level: a cluster-randomised.

Volume 18, Issue 6, Pages (June 2019)

Laparoscopic supracervical hysterectomy versus endometrial ablation for women with heavy menstrual bleeding (HEALTH): a parallel-group, open-label, randomised.

Volume 1, Issue 7, Pages (December 2014)

Presentation transcript:

Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial Dr Pallavi Mandal, MRCP, James D Chalmers, MRCP, Catriona Graham, MSc, Catherine Harley, MRCP, Manjit K Sidhu, MRCP, Catherine Doherty, PhD, Prof John W Govan, DSc, Prof Tariq Sethi, PhD, Donald J Davidson, PhD, Prof Adriano G Rossi, DSc, Adam T Hill, MD The Lancet Respiratory Medicine Volume 2, Issue 6, Pages 455-463 (June 2014) DOI: 10.1016/S2213-2600(14)70050-5 Copyright © 2014 Mandal et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions

Figure 1 Neutrophil apoptosis after treatment with atorvastatin Neutrophils (per 400 cells counted) are visualised by microscopy in a sample of sputum from a patient after 6 months of treatment with atorvastatin. Apoptotic neutrophils are indicated by arrows. Magnification ×1000. The Lancet Respiratory Medicine 2014 2, 455-463DOI: (10.1016/S2213-2600(14)70050-5) Copyright © 2014 Mandal et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions

Figure 2 Trial profile *Six patients discontinued for the following reasons: alanine aminotransferase level greater than five times the normal value (n=1); diarrhoea (n=1); headache and diarrhoea (n=2); headache (n=1); other reasons (n=1). †One patient discontinued for other reasons. The Lancet Respiratory Medicine 2014 2, 455-463DOI: (10.1016/S2213-2600(14)70050-5) Copyright © 2014 Mandal et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions

Figure 3 Reduction of cough, measured by Leicester Cough Questionnaire LCQ=Leicester Cough Questionnaire. (A) Atorvastatin group. (B) Placebo group. The Lancet Respiratory Medicine 2014 2, 455-463DOI: (10.1016/S2213-2600(14)70050-5) Copyright © 2014 Mandal et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions