Systematic review of the clinical efficacy of vaginal progesterone for luteal phase support in assisted reproductive technology cycles Tim Child, Saoirse.

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Presentation transcript:

Systematic review of the clinical efficacy of vaginal progesterone for luteal phase support in assisted reproductive technology cycles Tim Child, Saoirse A. Leonard, Jennifer S. Evans, Amir Lass Reproductive BioMedicine Online Volume 36, Issue 6, Pages 630-645 (June 2018) DOI: 10.1016/j.rbmo.2018.02.001 Copyright © 2018 The Author(s) Terms and Conditions

Figure 1 PRISMA flow diagram. ART = assisted reproductive technology; CDSR = Cochrane Database of Systematic Reviews; CENTRAL = Cochrane Central Register of Controlled Trials; DARE = Database of Abstracts of Reviews of Effects. Reproductive BioMedicine Online 2018 36, 630-645DOI: (10.1016/j.rbmo.2018.02.001) Copyright © 2018 The Author(s) Terms and Conditions

Figure 2 Network of evidence identified in the systematic literature review. Black lines represent trials with two comparators in the network, grey lines trials with three comparators in the network; line thickness denotes the number of trials making each comparison. A variety of outcomes were reported in the included trials and the network for any given outcome is likely to be smaller than that shown. Included trials: Bergh et al. (2012), Doody et al. (2009), Ganesh et al. (2011), Geber et al. (2007), Kleinstein (2005), Ludwig et al. (2002), Ng et al. (2003, 2007), Simunic et al. (2007), Tay and Lenton (2005). od = omni die (once daily); bd = bis die (twice daily); tid = ter in die (thrice daily). Reproductive BioMedicine Online 2018 36, 630-645DOI: (10.1016/j.rbmo.2018.02.001) Copyright © 2018 The Author(s) Terms and Conditions

Figure 3 Impact of Utrogestan Vaginal LPS duration on efficacy. #P = not significant, *statistical comparison not conducted. ET = embryo transfer; HCG = human chorionic gonadotrophin; LPS = luteal phase support; OR = oocyte retrieval. Reproductive BioMedicine Online 2018 36, 630-645DOI: (10.1016/j.rbmo.2018.02.001) Copyright © 2018 The Author(s) Terms and Conditions