Opportunity Knocks… (Should I Answer?) Kimberly E. Vanover, Ph.D. Executive Director, Clinical Development ASPET/APS Joint Mentoring Symposium April 21, 2009 K. Vanover - Pathways to Leadership

Opportunities Arise from Transitions From academia to industry From big pharma to biotech From bench scientist to management From drug discovery to clinical development From office commute to home office April 21, 2009 K. Vanover - Pathways to Leadership

K. Vanover - Pathways to Leadership Academia to Industry Skill Sets Grant writing Manuscripts Report writing Press releases Financial Pressures Grants Contracts Investors Partnerships Outlook Collaboration vs Competition Timeframe IP IP, intellectual property April 21, 2009 K. Vanover - Pathways to Leadership

Big Pharma to Biotech Big Pharma Biotech Specialization More money, Long timelines Risk of therapeutic area switch Biotech Many hats Hurry before the money runs out Risk of all eggs in one basket April 21, 2009 K. Vanover - Pathways to Leadership

Bench to Management Independence Conducting Own Experiments Analyzing Own Data More Physical Work Taking on Direct Reports Influencing Broader Scope Dealing with More People Problems Senior Management Influencing Large Strategic Decisions Increased Impact Increased Pressure April 21, 2009 K. Vanover - Pathways to Leadership

K. Vanover - Pathways to Leadership Discovery to Clinical Chemistry/CMC New Molecular Entity In Vitro In Vivo ADME/ DMPK Pre- Clinical Phase I Phase II Phase III New Drug Application Toxicology GLP GMP GCP Regulatory Affairs product Profile Target CROs ADME/DMPK, ; GCP, ; GLP, ; GMP, Data Management & Biostatistics Documentation Safety Formulations April 21, 2009 K. Vanover - Pathways to Leadership

Office Commute to Home Office Team Support Feel Connected “In the Know” Office Commute Self-Motivation Fewer Distractions More Flexibility Home Office April 21, 2009 K. Vanover - Pathways to Leadership

K. Vanover - Pathways to Leadership Transitions Allow for More Opportunity Learning broader skills Increasing flexibility & creativity Taking more responsibility April 21, 2009 K. Vanover - Pathways to Leadership

K. Vanover - Pathways to Leadership Opportunity dances with those already on the dance floor. H. Jackson Brown, Jr. (author) April 21, 2009 K. Vanover - Pathways to Leadership

Opportunity is Taken, Not Given Don’t wait for someone to hand opportunity on a silver platter Do take advantage of open doors Don’t say, “that’s not my job” Do look for what needs to be done and do it Set your goal and start working towards it Ask for what you want and ask for help April 21, 2009 K. Vanover - Pathways to Leadership

Opportunity Knocks… Should I Answer? Self Career Family Make Compromises Strike a Balance April 21, 2009 K. Vanover - Pathways to Leadership

K. Vanover - Pathways to Leadership Opportunity is missed by most people because it is dressed in overalls and looks like work. Thomas A. Edison (inventor, 1847 – 1931) April 21, 2009 K. Vanover - Pathways to Leadership