Sonia C Nicholson, MA, Marian Squier, MBBS, David J

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Presentation transcript:

Effect of Desferrioxamine Cardioplegia on Ischemia-Reperfusion Injury in Isolated Rat Heart Sonia C Nicholson, MA, Marian Squier, MBBS, David J.P Ferguson, DSc, Zsuzsanna Nagy, DPhil, Stephen Westaby, MS, Rhys D Evans, DPhil The Annals of Thoracic Surgery Volume 63, Issue 4, Pages 1003-1011 (April 1997) DOI: 10.1016/S0003-4975(96)01386-0

Fig. 1 Effect of desferrioxamine on coronary flow rate after 15, 30, and 45 minutes of reperfusion, expressed as a percentage of the baseline value (B). Baseline values are given in milliliters per minute. Results are expressed as the mean ± the standard error of the mean (n = 11 to 15). The Annals of Thoracic Surgery 1997 63, 1003-1011DOI: (10.1016/S0003-4975(96)01386-0)

Fig. 2 Effect of desferrioxamine on left ventricular diastolic function after 15, 30, and 45 minutes of reperfusion. Values are expressed as the percentage of the baseline value (B). Baseline values are given in millimeters mercury per second for the maximum rate of decrease of left ventricular pressure (maximum negative dP/dt), milliseconds for the time constant of relaxation, and milliliters−1 for the chamber stiffness coefficient. Results are expressed as the mean ± the standard error of the mean (n = 7 for each group). (∗p < 0.05, as tested by Student’s t test.) The Annals of Thoracic Surgery 1997 63, 1003-1011DOI: (10.1016/S0003-4975(96)01386-0)

Fig. 3 Effect of desferrioxamine on systolic function after 15, 30, and 45 minutes of reperfusion. Values are expressed as the percentage of the baseline value (B). Baseline values are given in millimeters mercury (systolic pressure) and millimeters mercury per second (maximum rate of increase of left ventricular pressure [maximum positive dP/dt]). Results are expressed as the mean ± the standard error of the mean (n = 7 for each group). No significant difference was observed between groups. The Annals of Thoracic Surgery 1997 63, 1003-1011DOI: (10.1016/S0003-4975(96)01386-0)

Fig. 4 Effect of desferrioxamine on coronary venous lactate production per gram of wet weight at baseline (B) and after 15, 30, and 45 minutes of reperfusion. Results are expressed as the mean ± the standard error of the mean (n = 7 for each group). († p < 0.05 compared with baseline values, as shown by Student’s t test; no significant differences between the two groups were observed.) The Annals of Thoracic Surgery 1997 63, 1003-1011DOI: (10.1016/S0003-4975(96)01386-0)

Fig. 5 Photomicrographs of rat heart showing atrioventricular node (arrow). Staining with periodic acid–Schiff was done after cold cardioplegic ischemia with desferrioxamine and reperfusion. Well-preserved glycogen stores are seen. (A, ×46; B, ×230; both before 33% reduction.) The Annals of Thoracic Surgery 1997 63, 1003-1011DOI: (10.1016/S0003-4975(96)01386-0)

Fig. 6 Transmission electron micrographs of rat cardiac myocytes after routine processing (A, B) or diaminobenzidine staining (C, D, E). (A) A well-preserved myocyte is seen adjacent to a capillary showing well-preserved mitochondria (Mi) with an electron-dense matrix and normal cristae. (Bar = 0.5 μm.) (En = endothelial cell.) (B) Part of a poorly preserved myocyte showing swollen electron-lucent mitochondria (Mi) with disrupted cristae. (Bar = 1 μm.) (C) Low-power view of part of myocyte with well-preserved mitochondria (Mi) showing lipid droplets (arrows) with electron-dense peroxidase product around their periphery. (Bar = 1 μm.) (D) Detail of two lipid droplets in which the electron-dense peroxidase product can be seen around the periphery (arrowheads). (Bar = 0.5 μm.) (E) Detail of the myocyte cytoplasm showing two densely stained peroxisomes (arrows) surrounded by mitochondria. (Bar = 0.5 μm.) The Annals of Thoracic Surgery 1997 63, 1003-1011DOI: (10.1016/S0003-4975(96)01386-0)