So Many Correlated Tests, So Little Time So Many Correlated Tests, So Little Time! Rapid Adjustment of P Values for Multiple Correlated Tests  Karen N. Conneely, Michael Boehnke  The American Journal of Human Genetics  Volume 81, Issue 6, Pages 1158-1168 (December 2007) DOI: 10.1086/522036 Copyright © 2007 The American Society of Human Genetics Terms and Conditions

Figure 1 Bivariate normal probability represented by PACT when L=2 for one-sided tests (A) and two-sided tests (B). Elliptical lines represent the contours of a bivariate normal density function with positive correlation. Shaded area represents the space (extending to infinity) over which the probability PACT is measured. The American Journal of Human Genetics 2007 81, 1158-1168DOI: (10.1086/522036) Copyright © 2007 The American Society of Human Genetics Terms and Conditions

Figure 2 LD (r2) between 20 SNPs from HNF1A The American Journal of Human Genetics 2007 81, 1158-1168DOI: (10.1086/522036) Copyright © 2007 The American Society of Human Genetics Terms and Conditions

Figure 3 Correlation structures used in simulations of 10 correlated traits. A, Uncorrelated traits. B, Equal correlation between traits. C, Autocorrelated traits. D, Independent blocks of correlated traits. E, Negatively correlated blocks of correlated traits. The American Journal of Human Genetics 2007 81, 1158-1168DOI: (10.1086/522036) Copyright © 2007 The American Society of Human Genetics Terms and Conditions

Figure 4 A, Estimates of PACT and Pperm for 3,007 SNPs tested for disease association under three genetic models. B, Estimates of PACT and Pperm for 3,584 SNPs tested for association with 18 quantitative traits. Unblackened circles represent 3,575 SNPs genotyped for the candidate-gene study. Blackened circles represent nine simulated SNPs. The American Journal of Human Genetics 2007 81, 1158-1168DOI: (10.1086/522036) Copyright © 2007 The American Society of Human Genetics Terms and Conditions