Multimodal Signal Integration for Feeding Control

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Multimodal Signal Integration for Feeding Control Marcus L. Basiri, Garret D. Stuber Cell Volume 165, Issue 3, Pages 522-523 (April 2016) DOI: 10.1016/j.cell.2016.04.022 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Ingestion Neurons (IN1) Reside in the Subesophageal Zone and Integrate Pharyngeal Gustatory Input with Hunger State to Modify Ingestion (A) Frontal view illustration of a Drosophila head during sucrose consumption, with brain (purple) and pertinent circuitry (green) overlaid. Region enclosed by line magnified in (B). (B) IN1 neurons reside in the subesophageal zone (SEZ) and receive synaptic input from sugar-sensitive gustatory neurons in the pharynx. IN1 neurons increase their activity in response to sucrose ingestion and display greater activity to higher sucrose concentrations. IN1 activity is greater in fasted flies and decreases over the course of ingestion as flies become satiated. Cell 2016 165, 522-523DOI: (10.1016/j.cell.2016.04.022) Copyright © 2016 Elsevier Inc. Terms and Conditions