A Histone Modifier’s Ill-Gotten Copy Gains

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A Histone Modifier’s Ill-Gotten Copy Gains Ryan Rickels, Ali Shilatifard Cell Volume 154, Issue 3, Pages 477-479 (August 2013) DOI: 10.1016/j.cell.2013.07.010 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 KDM4A Overexpression Promotes Local DNA Rereplication (A) HP1γ binds to methylated H3K9, blocking access to KDM4A and the DNA replication machinery. (B) To properly coordinate replication timing, KDM4A demethylates H3K9, promoting local DNA accessibility. (C) When overexpressed, KDM4A demethylase activity maintains different regions of chromatin in an uncondensed state, promoting aberrant DNA rereplication (red lines). Black et al. hypothesize that the extrachromosomal DNA copies result from head-to-tail polymerase collisions. Cell 2013 154, 477-479DOI: (10.1016/j.cell.2013.07.010) Copyright © 2013 Elsevier Inc. Terms and Conditions