Volume 24, Issue 1, Pages (March 2017)

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Volume 24, Issue 1, Pages 23-30 (March 2017) Rotenone impairs hippocampal neuronal activity in a rat model of Parkinson’s disease L.V. Darbinyan, L.E. Hambardzumyan, K.V. Simonyan, V.A. Chavushyan, L.P. Manukyan, V.H. Sarkisian Pathophysiology Volume 24, Issue 1, Pages 23-30 (March 2017) DOI: 10.1016/j.pathophys.2017.01.001 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 Experimental group (control-vehicle), mean frequency of spikes diagram for hippocampal neurons (vehicle group) exhibiting TP PTP, TP PTD, TD PTD, TD PTP, TD, TP responses, and non reactive neurons with indication of numeric values of spiking mean frequency (spikes/sec) in real time for 20s before HFS (M BE), 20s post HFS (M PE) and at HFS (M HFS). n − the number of neurons (frequency spike activity which averaged in the diagram) exhibiting the given type of responses. Pathophysiology 2017 24, 23-30DOI: (10.1016/j.pathophys.2017.01.001) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Experimental group (rotenone), mean frequency of spikes diagram for hippocampal neurons (rotenone group) exhibiting TP PTP, TP PTD, TD PTD, TD PTP, TD, TP, PTP responses, and nonreactive neurons with indication of numeric values of spiking mean frequency (spikes/sec) in real time for 20s before HFS (M BE), 20s post HFS (M PE) and at HFS (M HFS). n − the number of neurons (frequency spike activity which averaged in the diagram) exhibiting the given type of responses. Pathophysiology 2017 24, 23-30DOI: (10.1016/j.pathophys.2017.01.001) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Experimental group (norm), mean frequency of spikes diagram for hippocampal neurons (norm group) exhibiting TP PTP, TD PTD, TD PTP responses with indication of numeric values of spiking mean frequency (spikes/sec) in real time for 20s before HFS (M BE), 20s post HFS (M PE) and at HFS (M HFS). n − the number of neurons (frequency spike activity which averaged in the diagram) exhibiting the given type of responses. Pathophysiology 2017 24, 23-30DOI: (10.1016/j.pathophys.2017.01.001) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 4 Comparative averaged cumulative curves for TP PTP, TD PTD, TD PTP types of responses (rotenone-ROT, vehicle, norm). Pathophysiology 2017 24, 23-30DOI: (10.1016/j.pathophys.2017.01.001) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 5 Cylinder test (forelimb use asymmetry test in rats). The table shows control (vehicle-treated) and Rotenone-treated rats. Each value represents the mean+SEM. Values significantly different from those of the control group: p<0.05. Student's t-test. Pathophysiology 2017 24, 23-30DOI: (10.1016/j.pathophys.2017.01.001) Copyright © 2017 Elsevier B.V. Terms and Conditions