G. E. Gold, F. Cicuttini, M. D. Crema, F. Eckstein, A. Guermazi, R

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OARSI Clinical Trials Recommendations: Hip imaging in clinical trials in osteoarthritis G.E. Gold, F. Cicuttini, M.D. Crema, F. Eckstein, A. Guermazi, R. Kijowski, T.M. Link, E. Maheu, J. Martel-Pelletier, C.G. Miller, J.-P. Pelletier, C.G. Peterfy, H.G. Potter, F.W. Roemer, D.J. Hunter Osteoarthritis and Cartilage Volume 23, Issue 5, Pages 716-731 (May 2015) DOI: 10.1016/j.joca.2015.03.004 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 AP supine radiograph of the pelvis. Focus to film distance was approximately 100 cm, and digital detector was used. Osteoarthritis and Cartilage 2015 23, 716-731DOI: (10.1016/j.joca.2015.03.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 (a) Supine and (b) weight-bearing radiographs of the hip. Note the weight bearing view has overlying pannus that degrades image quality. Either image could be used to measure joint space width. Osteoarthritis and Cartilage 2015 23, 716-731DOI: (10.1016/j.joca.2015.03.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Standard MRI examination of the hip with two-dimensional fast or turbo spin-echo sequences. (a) Axial intermediate weighted MRI without fat suppression. (b) Axial T2-weighted MRI with fat suppression. (c) Coronal intermediate weighted MRI with fat suppression. (d) Coronal T1-weighted MRI without fat suppression. (e) Sagittal intermediate-weighted MRI with fat suppression. All relevant anatomy (bone, cartilage, joint fluid, labrum) can be evaluated on these images. Osteoarthritis and Cartilage 2015 23, 716-731DOI: (10.1016/j.joca.2015.03.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Reformations from an axial 0.8 mm isotropic 3D fast spin-echo acquisition at 3 T. (a) Coronal reformat, 3 mm slice. (b) Sagittal reformat, 3 mm slice. Osteoarthritis and Cartilage 2015 23, 716-731DOI: (10.1016/j.joca.2015.03.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 T1rho (left) and T2 (right) color maps of the hip in a healthy volunteer, for evaluation of cartilage matrix properties. T2 is correlated with collagen organization, and T1rho with proteoglycan content. Reproduced with permission from John Wiley and Sons (license number 3603340482801; J Magn Reson Imaging. 2015 Mar;41(3):doi: 10.1002/jmri.24868 Osteoarthritis and Cartilage 2015 23, 716-731DOI: (10.1016/j.joca.2015.03.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 (a) Coronal reformation of computed tomography study of the pelvis, demonstrating os acetabuli (arrow). (b) Three-dimensional shaded-surface display of the same hip, shown from a sagittal orientation. Arrows show the os acetabuli. Osteoarthritis and Cartilage 2015 23, 716-731DOI: (10.1016/j.joca.2015.03.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 7 T1-weighted fat-suppressed images from an MRI arthrogram in a subject with a history of femoroacetabular impingement. (a) Coronal image showing a labral tear (arrow). (b) Sagittal image showing an anterior labral tear. (c) Oblique axial image for measurement of alpha angle. Osteoarthritis and Cartilage 2015 23, 716-731DOI: (10.1016/j.joca.2015.03.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions