Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

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Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2017.32 Figure 2 Histopathology of NAFLD showing areas of macrosteatosis and microsteatosis Figure 2 | Histopathology of NAFLD showing areas of macrosteatosis and microsteatosis. A haematoxylin and eosin-stained tissue sample from a human showing hepatocytes exhibiting microvesicular (arrowheads) and macrovesicular (arrows) steatosis. Hepatocytes with microvesicular steatosis have abnormal accumulation of lipid with preserved cellular architecture, including a non-displaced nucleus, whereas hepatocytes with macrovesicular steatosis have one large droplet that displaces the nucleus. We thank S. Alexandrescu at Boston Children's Hospital, USA, for this image. We thank S. Alexandrescu at Boston Children’s Hospital, USA, for this image Gluchowski, N. L. et al. (2017) Lipid droplets and liver disease: from basic biology to clinical implications Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2017.32