Lifestyle Modification for the Management of Obesity Thomas A. Wadden, Meghan L. Butryn, Christopher Wilson  Gastroenterology  Volume 132, Issue 6, Pages 2226-2238 (May 2007) DOI: 10.1053/j.gastro.2007.03.051 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 Changes in body weight in participants in the Diabetes Prevention Program. Figure reprinted with permission from ref. 5. Copyright © 2002 Massachusetts Medical Society. All rights reserved. Gastroenterology 2007 132, 2226-2238DOI: (10.1053/j.gastro.2007.03.051) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 Cumulative incidence of diabetes in participants in the Diabetes Prevention Program study. The risk of developing diabetes was reduced by 58% in the lifestyle group compared to control and by 31% compared to metformin. Figure reprinted with permission from ref. 5. Copyright © 2002 Massachusetts Medical Society. All rights reserved. Gastroenterology 2007 132, 2226-2238DOI: (10.1053/j.gastro.2007.03.051) Copyright © 2007 AGA Institute Terms and Conditions

Figure 3 Macronutrient composition of several popular reducing diets. Figure adapted from data contained in refs. 51 and 65–70. The authors thank Dr. Peter Wilson for providing a prototype of the figure. Gastroenterology 2007 132, 2226-2238DOI: (10.1053/j.gastro.2007.03.051) Copyright © 2007 AGA Institute Terms and Conditions

Figure 4 Changes in body weight over 8 months in persons who were instructed to engage in different amounts (and intensities) of physical activity. The results show that walking the equivalent of 30 minutes a day, 6 days a week, induced a loss of only 1 kg in 8 months. Figure adapted from data in ref. 77. Gastroenterology 2007 132, 2226-2238DOI: (10.1053/j.gastro.2007.03.051) Copyright © 2007 AGA Institute Terms and Conditions

Figure 5 Long-term results of standard behavioral treatment with or without twice monthly maintenance therapy. Maintenance therapy was terminated at week 72. Figure adapted from data in refs. 24, 99, and 101. Gastroenterology 2007 132, 2226-2238DOI: (10.1053/j.gastro.2007.03.051) Copyright © 2007 AGA Institute Terms and Conditions

Figure 6 Potentially complementary mechanisms of action of pharmacotherapy and lifestyle modification in inducing weight loss. Gastroenterology 2007 132, 2226-2238DOI: (10.1053/j.gastro.2007.03.051) Copyright © 2007 AGA Institute Terms and Conditions

Figure 7 Mean percentage reduction in initial weight over 1 year for participants assigned to sibutramine alone, lifestyle modification alone, combined therapy, or sibutramine plus brief therapy. Weight losses in kilograms are reported in ref. 15. Gastroenterology 2007 132, 2226-2238DOI: (10.1053/j.gastro.2007.03.051) Copyright © 2007 AGA Institute Terms and Conditions

Thomas Wadden, MD, PhD Gastroenterology 2007 132, 2226-2238DOI: (10.1053/j.gastro.2007.03.051) Copyright © 2007 AGA Institute Terms and Conditions